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Target Report Card

Target Name and Classification

Target ID CHEMBL4598
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase MST1
Synonyms KRS2 | MST-1 | MST1 | MST1/C | MST1/N | Mammalian STE20-like protein kinase 1 | STE20-like kinase MST1 | STK4 | Serine/threonine-protein kinase 4 18kDa subunit | Serine/threonine-protein kinase 4 37kDa subunit | Serine/threonine-protein kinase 4 | Serine/threonine-protein kinase Krs-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase mst subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase 4 SINGLE PROTEIN Q13043

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101109
Ensembl ENSG00000101109
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0043234 (protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043539 (protein serine/threonine kinase activator activity)
GO:0046872 (metal ion binding)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0000902 (cell morphogenesis)
GO:0001569 (patterning of blood vessels)
GO:0001841 (neural tube formation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0003157 (endocardium development)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007417 (central nervous system development)
GO:0008285 (negative regulation of cell proliferation)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030216 (keratinocyte differentiation)
GO:0032092 (positive regulation of protein binding)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0035329 (hippo signaling)
GO:0035556 (intracellular signal transduction)
GO:0043065 (positive regulation of apoptotic process)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0046621 (negative regulation of organ growth)
GO:0046777 (protein autophosphorylation)
GO:0050821 (protein stabilization)
GO:0060215 (primitive hemopoiesis)
GO:0060706 (cell differentiation involved in embryonic placenta development)
GO:0060800 (regulation of cell differentiation involved in embryonic placenta development)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0097284 (hepatocyte apoptotic process)
GO:1902043 (positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)
Wikipedia STK4

Target Cross References - Protein

canSAR Q13043
CGD T-cell immunodeficiency syndrome with recurrent infections, autoimmunity, with and without cardiac malformations
Human Protein Atlas ENSG00000101109
IntAct Q13043
Guide to Pharmacology 2225
Open Targets ENSG00000101109
PharmGKB PA36215
Pharos Q13043 (Tchem)
Reactome R-HSA-2028269 (Signaling by Hippo.)
UniProt B2RCR8 Q13043 Q15802 Q4G156 Q5H982 Q6PD60 Q9BR32 Q9NTZ4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR011524 (SARAH_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR024205 (Mst1_SARAH_domain.)
Pfam PF00069 (Pkinase)
PF11629 (Mst1_SARAH)

Target Cross References - Structure

PDBe 3COM 4NR2 4OH8
CREDO 3COM 4NR2 4OH8
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