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Target Report Card

Target Name and Classification

Target ID CHEMBL4596
Preferred Name C-C chemokine receptor type 8
Synonyms C-C CKR-8 | C-C chemokine receptor type 8 | CC chemokine receptor CHEMR1 | CC-CKR-8 | CCR-8 | CCR8 | CD_antigen=CDw198 | CKR-L1 | CKRL1 | CMKBR8 | CMKBRL2 | CMKBRL2 | Chemokine receptor-like 1 | GPR-CY6 | GPRCY6 | TER1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 8 SINGLE PROTEIN P51685

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000179934
Ensembl ENSG00000179934
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0015026 (coreceptor activity)
GO:0016493 (C-C chemokine receptor activity)
GO Biological Process GO:0006935 (chemotaxis)
GO:0006955 (immune response)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0070098 (chemokine-mediated signaling pathway)
Wikipedia CCR8_(gene)

Target Cross References - Protein

canSAR P51685
Human Protein Atlas ENSG00000179934
Guide to Pharmacology 65
Open Targets ENSG00000179934
PharmGKB PA26173
Pharos P51685 (Tchem)
Reactome R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt B2RC64 P51685 Q3KNQ8 Q3KNR3 Q9BYX5

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR004068 (Chemokine_CCR8.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)