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Target Report Card

Target Name and Classification

Target ID CHEMBL4594
Target Type SINGLE PROTEIN
Preferred Name C-C chemokine receptor type 7
Synonyms BLR2 | C-C CKR-7 | C-C chemokine receptor type 7 | CC-CKR-7 | CCR-7 | CCR7 | CD_antigen=CD197 | CDw197 | CMKBR7 | EBI1 | EBI1 | EBV-induced G-protein coupled receptor 1 | EVI1 | Epstein-Barr virus-induced G-protein coupled receptor 1 | MIP-3 beta receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 7 SINGLE PROTEIN P32248

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000126353
Ensembl ENSG00000126353
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0016493 (C-C chemokine receptor activity)
GO:0035757 (chemokine (C-C motif) ligand 19 binding)
GO:0035758 (chemokine (C-C motif) ligand 21 binding)
GO:0038117 (C-C motif chemokine 19 receptor activity)
GO:0038121 (C-C motif chemokine 21 receptor activity)
GO Biological Process GO:0001768 (establishment of T cell polarity)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0002407 (dendritic cell chemotaxis)
GO:0002408 (myeloid dendritic cell chemotaxis)
GO:0002606 (positive regulation of dendritic cell antigen processing and presentation)
GO:0002885 (positive regulation of hypersensitivity)
GO:0002922 (positive regulation of humoral immune response)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031274 (positive regulation of pseudopodium assembly)
GO:0031529 (ruffle organization)
GO:0032496 (response to lipopolysaccharide)
GO:0032649 (regulation of interferon-gamma production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0034695 (response to prostaglandin E)
GO:0038115 (chemokine (C-C motif) ligand 19 signaling pathway)
GO:0038116 (chemokine (C-C motif) ligand 21 signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045060 (negative thymic T cell selection)
GO:0045785 (positive regulation of cell adhesion)
GO:0045860 (positive regulation of protein kinase activity)
GO:0046330 (positive regulation of JNK cascade)
GO:0048872 (homeostasis of number of cells)
GO:0050706 (regulation of interleukin-1 beta secretion)
GO:0050862 (positive regulation of T cell receptor signaling pathway)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051491 (positive regulation of filopodium assembly)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0070098 (chemokine-mediated signaling pathway)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071731 (response to nitric oxide)
GO:0072610 (interleukin-12 secretion)
GO:0090023 (positive regulation of neutrophil chemotaxis)
GO:0090630 (activation of GTPase activity)
GO:0097022 (lymphocyte migration into lymph node)
GO:0097029 (mature conventional dendritic cell differentiation)
GO:2000107 (negative regulation of leukocyte apoptotic process)
GO:2000147 (positive regulation of cell motility)
GO:2000510 (positive regulation of dendritic cell chemotaxis)
GO:2000522 (positive regulation of immunological synapse formation)
GO:2000525 (positive regulation of T cell costimulation)
GO:2000526 (positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation)
GO:2000547 (regulation of dendritic cell dendrite assembly)
Wikipedia C-C_chemokine_receptor_type_7

Target Cross References - Protein

canSAR P32248
Human Protein Atlas ENSG00000126353
IntAct P32248
Guide to Pharmacology 64
Open Targets ENSG00000126353
PharmGKB PA26172
Pharos P32248 (Tbio)
Reactome R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P32248

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR001718 (Chemokine_CCR7.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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