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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4588
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase 8
Synonyms CLG1 | MMP-8 | MMP8 | Matrix metalloproteinase-8 | Neutrophil collagenase | PMNL collagenase | PMNL-CL
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Neutrophil collagenase SINGLE PROTEIN P22894

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095216 Collagenase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200567 DOXYCYCLINE HYCLATE Matrix metalloproteinase 8 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL1200699 DOXYCYCLINE HYDRATE Matrix metalloproteinase 8 inhibitor 4 DailyMed PubMed PubMed PubMed
CHEMBL2364574 DOXYCYCLINE CALCIUM Matrix metalloproteinase 8 inhibitor 4 DailyMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118113
Ensembl ENSG00000118113
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0031012 (extracellular matrix)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0035987 (endodermal cell differentiation)
Wikipedia MMP8

Target Cross References - Protein

canSAR P22894
Human Protein Atlas ENSG00000118113
Guide to Pharmacology 1632
Open Targets ENSG00000118113
PharmGKB PA30888
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
UniProt P22894 Q45F99

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR016293 (Pept_M10A_stromelysin-type.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom.)
IPR028709 (MMP8.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)

Target Cross References - Structure

PDBe 1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4 4QKZ
CREDO 1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4 4QKZ
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