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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4578
Target Type SINGLE PROTEIN
Preferred Name Maternal embryonic leucine zipper kinase
Synonyms KIAA0175 | MELK | Maternal embryonic leucine zipper kinase | Protein kinase Eg3 | Protein kinase PK38 | Tyrosine-protein kinase MELK | hMELK | hPK38 | pEg3 kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase melk subfamily

Target Components

Component Description Relationship Accession
Maternal embryonic leucine zipper kinase SINGLE PROTEIN Q14680

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165304
Ensembl ENSG00000165304
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005938 (cell cortex)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008289 (lipid binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0008283 (cell proliferation)
GO:0008631 (intrinsic apoptotic signaling pathway in response to oxidative stress)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030097 (hemopoiesis)
GO:0035556 (intracellular signal transduction)
GO:0043065 (positive regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:0061351 (neural precursor cell proliferation)
Wikipedia MELK

Target Cross References - Protein

canSAR Q14680
Human Protein Atlas ENSG00000165304
IntAct Q14680
Guide to Pharmacology 2102
Open Targets ENSG00000165304
PharmGKB PA134902874
Pharos Q14680 (Tchem)
UniProt A6P3A7 A6P3A8 B1AMQ6 B7Z1E6 B7Z5M5 B7Z6Q7 B7Z6R8 B7Z6Y0 B7Z7Q1 D3DRP8 F5H0Y0 F5H2R4 F5H689 Q14680 Q7L3C3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001772 (KA1_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028375 (KA1/Ssp2_C.)
IPR033624 (MARK/par1.)
Pfam PF00069 (Pkinase)
PF02149 (KA1)

Target Cross References - Structure

PDBe 4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC
CREDO 4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC
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