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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4550
Target Type SINGLE PROTEIN
Preferred Name 5-lipoxygenase activating protein
Synonyms ALOX5AP | Arachidonate 5-lipoxygenase-activating protein | FLAP | FLAP | MK-886-binding protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Arachidonate 5-lipoxygenase-activating protein SINGLE PROTEIN P20292

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111402 5-lipoxygenase/FLAP PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1922660 FIBOFLAPON 5-lipoxygenase activating protein inhibitor 3 PubMed PubMed
CHEMBL1922673 FIBOFLAPON SODIUM 5-lipoxygenase activating protein inhibitor 3 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132965
Ensembl ENSG00000132965
GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0004464 (leukotriene-C4 synthase activity)
GO:0004602 (glutathione peroxidase activity)
GO:0005515 (protein binding)
GO:0008047 (enzyme activator activity)
GO:0047485 (protein N-terminus binding)
GO:0050544 (arachidonic acid binding)
GO Biological Process GO:0006691 (leukotriene metabolic process)
GO:0019370 (leukotriene biosynthetic process)
GO:0019372 (lipoxygenase pathway)
GO:0043085 (positive regulation of catalytic activity)
GO:0070207 (protein homotrimerization)
GO:0071277 (cellular response to calcium ion)
GO:2001300 (lipoxin metabolic process)
Wikipedia 5-lipoxygenase-activating_protein

Target Cross References - Protein

canSAR P20292
Human Protein Atlas ENSG00000132965
IntAct P20292
Open Targets ENSG00000132965
PharmGKB PA47
Reactome R-HSA-2142688 (Synthesis of 5-eicosatetraenoic acids.)
R-HSA-2142691 (Synthesis of Leukotrienes (LT) and Eoxins (EX).)
R-HSA-2142700 (Synthesis of Lipoxins (LX).)
UniProt P20292 Q5VV04

Target Cross References - Domain

InterPro IPR001129 (Membr-assoc_MAPEG.)
IPR001446 (5_LipOase_AP.)
IPR018295 (FLAP/GST2/LTC4S_CS.)
IPR023352 (MAPEG-like_dom.)
Pfam PF01124 (MAPEG)

Target Cross References - Structure

PDBe 2Q7M 2Q7R
CREDO 2Q7M 2Q7R
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