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Target Report Card

Target Name and Classification

Target ID CHEMBL4549
Preferred Name Apolipoprotein B-100
Synonyms APOB | Apo B-100 | Apo B-48 | Apolipoprotein B-100 | Apolipoprotein B-48
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Apolipoprotein B-100 SINGLE PROTEIN P04114

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000084674
Ensembl ENSG00000084674
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005790 (smooth endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO:0012506 (vesicle membrane)
GO:0030669 (clathrin-coated endocytic vesicle membrane)
GO:0031904 (endosome lumen)
GO:0031983 (vesicle lumen)
GO:0034359 (mature chylomicron)
GO:0034360 (chylomicron remnant)
GO:0034361 (very-low-density lipoprotein particle)
GO:0034362 (low-density lipoprotein particle)
GO:0034363 (intermediate-density lipoprotein particle)
GO:0042627 (chylomicron)
GO:0043025 (neuronal cell body)
GO:0043202 (lysosomal lumen)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO:0070971 (endoplasmic reticulum exit site)
GO:0071682 (endocytic vesicle lumen)
GO Molecular Function GO:0005319 (lipid transporter activity)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0008201 (heparin binding)
GO:0008289 (lipid binding)
GO:0017127 (cholesterol transporter activity)
GO:0035473 (lipase binding)
GO:0050750 (low-density lipoprotein particle receptor binding)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0001701 (in utero embryonic development)
GO:0002224 (toll-like receptor signaling pathway)
GO:0006629 (lipid metabolic process)
GO:0006642 (triglyceride mobilization)
GO:0006869 (lipid transport)
GO:0006898 (receptor-mediated endocytosis)
GO:0007283 (spermatogenesis)
GO:0007399 (nervous system development)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0009566 (fertilization)
GO:0009615 (response to virus)
GO:0009743 (response to carbohydrate)
GO:0009791 (post-embryonic development)
GO:0010033 (response to organic substance)
GO:0010269 (response to selenium ion)
GO:0010628 (positive regulation of gene expression)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0010884 (positive regulation of lipid storage)
GO:0010886 (positive regulation of cholesterol storage)
GO:0016042 (lipid catabolic process)
GO:0019433 (triglyceride catabolic process)
GO:0030301 (cholesterol transport)
GO:0030317 (sperm motility)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0033344 (cholesterol efflux)
GO:0034371 (chylomicron remodeling)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0034378 (chylomicron assembly)
GO:0034379 (very-low-density lipoprotein particle assembly)
GO:0034382 (chylomicron remnant clearance)
GO:0034383 (low-density lipoprotein particle clearance)
GO:0034447 (very-low-density lipoprotein particle clearance)
GO:0042157 (lipoprotein metabolic process)
GO:0042158 (lipoprotein biosynthetic process)
GO:0042159 (lipoprotein catabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0042953 (lipoprotein transport)
GO:0043687 (post-translational protein modification)
GO:0044267 (cellular protein metabolic process)
GO:0045540 (regulation of cholesterol biosynthetic process)
GO:0048844 (artery morphogenesis)
GO:0050900 (leukocyte migration)
GO:0061024 (membrane organization)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071379 (cellular response to prostaglandin stimulus)
Wikipedia Apolipoprotein_B

Target Cross References - Protein

CGD Hypobetalipoproteinemia, familial; Hypercholesterolemia, familial
Human Protein Atlas ENSG00000084674
IntAct P04114
Open Targets ENSG00000084674
PharmGKB PA50
Reactome R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-3000471 (Scavenging by Class B Receptors.)
R-HSA-3000480 (Scavenging by Class A Receptors.)
R-HSA-3000484 (Scavenging by Class F Receptors.)
R-HSA-3000497 (Scavenging by Class H Receptors.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-432142 (Platelet sensitization by LDL.)
R-HSA-5686938 (Regulation of TLR by endogenous ligand.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
R-HSA-8866423 (VLDL assembly.)
R-HSA-8957275 (Post-translational protein phosphorylation.)
R-HSA-8963888 (Chylomicron assembly.)
R-HSA-8963901 (Chylomicron remodeling.)
R-HSA-8964026 (Chylomicron clearance.)
R-HSA-8964038 (LDL clearance.)
R-HSA-8964041 (LDL remodeling.)
R-HSA-8964046 (VLDL clearance.)
R-HSA-975634 (Retinoid metabolism and transport.)
UniProt O00502 P04114 P78479 P78480 P78481 Q13779 Q13785 Q13786 Q13787 Q13788 Q4ZG63 Q53QC8 Q7Z600 Q9UMN0

Target Cross References - Domain

InterPro IPR001747 (Lipid_transpt_N.)
IPR009454 (Lipid_transpt_open_b-sht.)
IPR011030 (Lipovitellin_superhlx_dom.)
IPR015255 (Vitellinogen_open_b-sht.)
IPR015816 (Vitellinogen_b-sht_N.)
IPR015819 (Lipid_transp_b-sht_shell.)
IPR016024 (ARM-type_fold.)
IPR022176 (ApoB100_C.)
Pfam PF01347 (Vitellogenin_N)
PF06448 (DUF1081)
PF09172 (DUF1943)
PF12491 (ApoB100_C)