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Target Report Card

Target Name and Classification

Target ID CHEMBL4549
Preferred Name Apolipoprotein B-100
Synonyms APOB | Apo B-100 | Apo B-48 | Apolipoprotein B-100 | Apolipoprotein B-48
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Apolipoprotein B-100 SINGLE PROTEIN P04114

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000084674
Ensembl ENSG00000084674
GO Cellular Component GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005792 (microsome)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO:0030669 (clathrin-coated endocytic vesicle membrane)
GO:0031904 (endosome lumen)
GO:0034359 (mature chylomicron)
GO:0034360 (chylomicron remnant)
GO:0034361 (very-low-density lipoprotein particle)
GO:0034362 (low-density lipoprotein particle)
GO:0034363 (intermediate-density lipoprotein particle)
GO Molecular Function GO:0005543 (phospholipid binding)
GO:0008201 (heparin binding)
GO:0017127 (cholesterol transporter activity)
GO:0019899 (enzyme binding)
GO:0046982 (protein heterodimerization activity)
GO:0050750 (low-density lipoprotein particle receptor binding)
GO Biological Process GO:0006898 (receptor-mediated endocytosis)
GO:0008203 (cholesterol metabolic process)
GO:0009615 (response to virus)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0010886 (positive regulation of cholesterol storage)
GO:0030168 (platelet activation)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0034383 (low-density lipoprotein particle clearance)
GO:0042632 (cholesterol homeostasis)
GO:0050900 (leukocyte migration)
Wikipedia Apolipoprotein_B

Target Cross References - Protein

CGD Hypobetalipoproteinemia, familial; Hypercholesterolemia, familial
Human Protein Atlas ENSG00000084674
PharmGKB PA50
Reactome REACT_22258 (Metabolism of lipids and lipoproteins.)
REACT_604 (Hemostasis.)
UniProt O00502 P04114 P78479 P78480 P78481 Q13779 Q13785 Q13786 Q13787 Q13788 Q4ZG63 Q53QC8 Q7Z600 Q9UMN0

Target Cross References - Domain

InterPro IPR001747 (Lipid_transpt_N.)
IPR009454 (Lipid_transpt_open_b-sht.)
IPR011030 (Vitellinogen_superhlx.)
IPR015255 (Vitellinogen_open_b-sht.)
IPR015816 (Vitellinogen_b-sht_N.)
IPR015817 (Vitellinogen_open_b-sht_sub1.)
IPR015818 (Vitellinogen_open_b-sht_sub2.)
IPR015819 (Lipid_transp_b-sht_shell.)
IPR022176 (ApoB100_C.)
Pfam PF01347 (Vitellogenin_N)
PF06448 (DUF1081)
PF09172 (DUF1943)
PF12491 (ApoB100_C)