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Target Report Card

Target Name and Classification

Target ID CHEMBL4531
Target Type SINGLE PROTEIN
Preferred Name Galectin-3
Synonyms 35 kDa lectin | CBP 35 | Carbohydrate-binding protein 35 | GALBP | Gal-3 | Galactose-specific lectin 3 | Galactoside-binding protein | Galectin-3 | IgE-binding protein | L-31 | LGALS3 | Laminin-binding protein | Lectin L-29 | MAC2 | Mac-2 antigen
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Galectin-3 SINGLE PROTEIN P17931

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131981
Ensembl ENSG00000131981
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005681 (spliceosomal complex)
GO:0005737 (cytoplasm)
GO:0005743 (mitochondrial inner membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005515 (protein binding)
GO:0019863 (IgE binding)
GO:0030246 (carbohydrate binding)
GO:0042056 (chemoattractant activity)
GO:0043236 (laminin binding)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0002376 (immune system process)
GO:0002548 (monocyte chemotaxis)
GO:0006397 (mRNA processing)
GO:0008380 (RNA splicing)
GO:0030154 (cell differentiation)
GO:0030593 (neutrophil chemotaxis)
GO:0030855 (epithelial cell differentiation)
GO:0042129 (regulation of T cell proliferation)
GO:0045087 (innate immune response)
GO:0045806 (negative regulation of endocytosis)
GO:0048245 (eosinophil chemotaxis)
GO:0048246 (macrophage chemotaxis)
GO:0050860 (negative regulation of T cell receptor signaling pathway)
GO:0050918 (positive chemotaxis)
GO:0070232 (regulation of T cell apoptotic process)
GO:0071674 (mononuclear cell migration)
GO:0071677 (positive regulation of mononuclear cell migration)
GO:0090280 (positive regulation of calcium ion import)
GO:1902041 (regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:2000521 (negative regulation of immunological synapse formation)
GO:2001189 (negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)
GO:2001200 (positive regulation of dendritic cell differentiation)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia LGALS3

Target Cross References - Protein

canSAR P17931
Human Protein Atlas ENSG00000131981
IntAct P17931
Open Targets ENSG00000131981
PharmGKB PA30340
Reactome R-HSA-879415 (Advanced glycosylation endproduct receptor signaling.)
UniProt B2RC38 P17931 Q16005 Q6IBA7 Q96J47

Target Cross References - Domain

InterPro IPR001079 (Galectin_CRD.)
IPR013320 (ConA-like_dom.)
Pfam PF00337 (Gal-bind_lectin)

Target Cross References - Structure

PDBe 1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK More...
CREDO 1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK More...
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