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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4530
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor XIII
Synonyms Coagulation factor XIII A chain | Coagulation factor XIIIa | F13A | F13A1 | Protein-glutamine gamma-glutamyltransferase A chain | Transglutaminase A chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > aminoacyltransferase > protein-glutamine glutamyl-transferase

Target Components

Component Description Relationship Accession
Coagulation factor XIII A chain SINGLE PROTEIN P00488

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124491
Ensembl ENSG00000124491
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0031093 (platelet alpha granule lumen)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0003810 (protein-glutamine gamma-glutamyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0018149 (peptide cross-linking)
GO:0042060 (wound healing)
Wikipedia Coagulation_factor_XIII,_A1_polypeptide

Target Cross References - Protein

canSAR P00488
CGD Factor XIIIA deficiency
Human Protein Atlas ENSG00000124491
IntAct P00488
Open Targets ENSG00000124491
PharmGKB PA162
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-140875 (Common Pathway of Fibrin Clot Formation.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt P00488 Q59HA7 Q8N6X2 Q96P24 Q9BX29

Target Cross References - Domain

InterPro IPR001102 (Transglutaminase_N.)
IPR002931 (Transglutaminase-like.)
IPR008958 (Transglutaminase_C.)
IPR013783 (Ig-like_fold.)
IPR013808 (Transglutaminase_AS.)
IPR014756 (Ig_E-set.)
IPR023608 (Gln_gamma-glutamylTfrase_euk.)
Pfam PF00868 (Transglut_N)
PF00927 (Transglut_C)
PF01841 (Transglut_core)

Target Cross References - Structure

PDBe 1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK 4KTY
CREDO 1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK 4KTY
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