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Target Report Card

Target Name and Classification

Target ID CHEMBL4528
Preferred Name Hyaluronidase-1
Synonyms HYAL1 | Hyal-1 | Hyaluronidase-1 | Hyaluronoglucosaminidase-1 | LUCA1 | LuCa-1 | Lung carcinoma protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hyaluronidase-1 SINGLE PROTEIN Q12794

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000114378
Ensembl ENSG00000114378
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0031410 (cytoplasmic vesicle)
GO:0036117 (hyaluranon cable)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0003824 (catalytic activity)
GO:0004415 (hyalurononglucosaminidase activity)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0050501 (hyaluronan synthase activity)
GO Biological Process GO:0000302 (response to reactive oxygen species)
GO:0005975 (carbohydrate metabolic process)
GO:0006954 (inflammatory response)
GO:0008152 (metabolic process)
GO:0009615 (response to virus)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0030207 (chondroitin sulfate catabolic process)
GO:0030212 (hyaluronan metabolic process)
GO:0030213 (hyaluronan biosynthetic process)
GO:0030214 (hyaluronan catabolic process)
GO:0030307 (positive regulation of cell growth)
GO:0030308 (negative regulation of cell growth)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0044344 (cellular response to fibroblast growth factor stimulus)
GO:0045766 (positive regulation of angiogenesis)
GO:0045785 (positive regulation of cell adhesion)
GO:0045927 (positive regulation of growth)
GO:0046677 (response to antibiotic)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0051216 (cartilage development)
GO:0060272 (embryonic skeletal joint morphogenesis)
GO:0071347 (cellular response to interleukin-1)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071467 (cellular response to pH)
GO:0071493 (cellular response to UV-B)
GO:1900106 (positive regulation of hyaluranon cable assembly)
Wikipedia HYAL1

Target Cross References - Protein

canSAR Q12794
CGD Mucopolysaccharidosis type IX
Human Protein Atlas ENSG00000114378
IntAct Q12794
Open Targets ENSG00000114378
PharmGKB PA29571
Reactome R-HSA-2024101 (CS/DS degradation.)
R-HSA-2160916 (Hyaluronan uptake and degradation.)
R-HSA-2206280 (MPS IX - Natowicz syndrome.)
UniProt Q12794 Q6FH23 Q6PIZ6 Q7KYU2 Q7LE34 Q8NFK5 Q8NFK6 Q8NFK7 Q8NFK8 Q8NFK9 Q93013 Q9UKD5 Q9UNI8

Target Cross References - Domain

InterPro IPR013785 (Aldolase_TIM.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR018155 (Hyaluronidase.)
Pfam PF01630 (Glyco_hydro_56)

Target Cross References - Structure