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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4523
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PIM2
Synonyms PIM2 | Pim-2h | Serine/threonine-protein kinase pim-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase pim family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase pim-2 SINGLE PROTEIN Q9P1W9

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102096
Ensembl ENSG00000102096
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006916 (anti-apoptosis)
GO:0007140 (male meiosis)
GO:0008283 (cell proliferation)
GO:0009615 (response to virus)
GO:0010508 (positive regulation of autophagy)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
Wikipedia PIM2_(gene)

Target Cross References - Protein

canSAR Q9P1W9
Human Protein Atlas ENSG00000102096
IntAct Q9P1W9
Guide to Pharmacology 2159 (Pim-2 proto-oncogene, serine/threonine kinase)
PharmGKB PA33319
UniProt A8K4G6 Q99739 Q9P1W9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2IWI
CREDO 2IWI
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