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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4523
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PIM2
Synonyms PIM2 | Pim-2h | Serine/threonine-protein kinase pim-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase pim family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase pim-2 SINGLE PROTEIN Q9P1W9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559682 Serine/threonine-protein kinase PIM PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102096
Ensembl ENSG00000102096
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007140 (male meiosis)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008283 (cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009615 (response to virus)
GO:0010508 (positive regulation of autophagy)
GO:0016310 (phosphorylation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046777 (protein autophosphorylation)
GO:0050821 (protein stabilization)
Wikipedia PIM2_(gene)

Target Cross References - Protein

canSAR Q9P1W9
Human Protein Atlas ENSG00000102096
IntAct Q9P1W9
Guide to Pharmacology 2159
Open Targets ENSG00000102096
PharmGKB PA33319
Pharos Q9P1W9 (Tchem)
UniProt A8K4G6 Q99739 Q9P1W9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017348 (PIM1/2/3.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2IWI 4X7Q
CREDO 2IWI 4X7Q
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