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Target Report Card

Target Name and Classification

Target ID CHEMBL4521
Preferred Name Cytochrome P450 24A1
Synonyms 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | 24-OHase | CYP24 | CYP24A1 | Cytochrome P450 24A1 | Cytochrome P450-CC24 | Vitamin D(3) 24-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial SINGLE PROTEIN Q07973

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000019186
Ensembl ENSG00000019186
GO Cellular Component GO:0005743 (mitochondrial inner membrane)
GO Molecular Function GO:0009055 (electron carrier activity)
GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen)
GO:0020037 (heme binding)
GO:0030342 (1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity)
GO Biological Process GO:0001649 (osteoblast differentiation)
GO:0006805 (xenobiotic metabolic process)
GO:0042369 (vitamin D catabolic process)
GO:0042446 (hormone biosynthetic process)
GO:0070561 (vitamin D receptor signaling pathway)
Wikipedia CYP24A1

Target Cross References - Protein

canSAR Q07973
CGD 1,25(OH)(2)D-24-hydroxylase deficiency
Human Protein Atlas ENSG00000019186
Guide to Pharmacology 1365 (CYP24A1)
PharmGKB PA27097
Reactome REACT_11193 (Metabolism of vitamins and cofactors.)
REACT_13433 (Biological oxidations.)
REACT_15314 (Hormone biosynthesis.)
REACT_22258 (Metabolism of lipids and lipoproteins.)
UniProt Q07973 Q15807

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)