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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4501
Target Type SINGLE PROTEIN
Preferred Name Ribosomal protein S6 kinase 1
Synonyms 70 kDa ribosomal protein S6 kinase 1 | P70S6K1 | RPS6KB1 | Ribosomal protein S6 kinase I | Ribosomal protein S6 kinase beta-1 | S6K-beta-1 | S6K1 | STK14A | Serine/threonine-protein kinase 14A | p70 S6 kinase alpha | p70 S6K-alpha | p70 S6KA | p70 ribosomal S6 kinase alpha | p70-S6K 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase p70 subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase beta-1 SINGLE PROTEIN P23443

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111330 Ribosomal protein S6 kinase (P70S6K) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108443
Ensembl ENSG00000108443
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0019717 (synaptosome)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO Molecular Function GO:0004672 (protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0006915 (apoptosis)
GO:0008286 (insulin receptor signaling pathway)
GO:0031929 (TOR signaling cascade)
GO:0043066 (negative regulation of apoptosis)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0045948 (positive regulation of translational initiation)
GO:0048015 (phosphatidylinositol-mediated signaling)
Wikipedia P70-S6_Kinase_1

Target Cross References - Protein

canSAR P23443
Human Protein Atlas ENSG00000108443
IntAct P23443
Guide to Pharmacology 1525 (ribosomal protein S6 kinase, 70kDa, polypeptide 1)
PharmGKB PA34851
Reactome REACT_498 (Signaling by Insulin receptor.)
UniProt P23443

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000961 (AGC-kinase_C.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR016238 (Ribosomal_S6_kinase.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 3A60 3A61 3A62
CREDO 3A60 3A61 3A62
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