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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4499
Target Type SINGLE PROTEIN
Preferred Name NADH-ubiquinone oxidoreductase chain 4
Synonyms MT-ND4 | MTND4 | NADH dehydrogenase subunit 4 | NADH-ubiquinone oxidoreductase chain 4 | NADH4 | ND4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
NADH-ubiquinone oxidoreductase chain 4 SINGLE PROTEIN P03905

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363065 Mitochondrial complex I (NADH dehydrogenase) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198886
Ensembl ENSG00000198886
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005747 (mitochondrial respiratory chain complex I)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031966 (mitochondrial membrane)
GO:0070469 (respiratory chain)
GO Molecular Function GO:0008137 (NADH dehydrogenase (ubiquinone) activity)
GO:0016491 (oxidoreductase activity)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001701 (in utero embryonic development)
GO:0006120 (mitochondrial electron transport, NADH to ubiquinone)
GO:0007568 (aging)
GO:0021549 (cerebellum development)
GO:0032981 (mitochondrial respiratory chain complex I assembly)
GO:0035094 (response to nicotine)
GO:0042773 (ATP synthesis coupled electron transport)
GO:0045471 (response to ethanol)
GO:0055114 (oxidation-reduction process)
Wikipedia MT-ND4

Target Cross References - Protein

canSAR P03905
CGD Leber hereditary optic neuropathy; Leber optic atrophy and dystonia; Mitochondrial complex I deficiency
Human Protein Atlas ENSG00000198886
IntAct P03905
Open Targets ENSG00000198886
PharmGKB PA31263
Reactome R-HSA-611105 (Respiratory electron transport.)
R-HSA-6799198 (Complex I biogenesis.)
UniProt P03905 Q6RL39 Q6RQN9 Q8HNR8

Target Cross References - Domain

InterPro IPR000260 (NADH4_N.)
IPR001750 (ND/Mrp_mem.)
IPR003918 (NADH_UbQ_OxRdtase.)
IPR010227 (NADH_Q_OxRdtase_chainM/4.)
Pfam PF00361 (Proton_antipo_M)
PF01059 (Oxidored_q5_N)
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