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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4499
Preferred Name NADH-ubiquinone oxidoreductase chain 4
Synonyms MT-ND4 | MTND4 | NADH dehydrogenase subunit 4 | NADH-ubiquinone oxidoreductase chain 4 | NADH4 | ND4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
NADH-ubiquinone oxidoreductase chain 4 SINGLE PROTEIN P03905

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363065 Mitochondrial complex I (NADH dehydrogenase) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000198886
Ensembl ENSG00000198886
GO Cellular Component GO:0005747 (mitochondrial respiratory chain complex I)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0008137 (NADH dehydrogenase (ubiquinone) activity)
GO Biological Process GO:0006120 (mitochondrial electron transport, NADH to ubiquinone)
GO:0006810 (transport)
Wikipedia MT-ND4

Target Cross References - Protein

canSAR P03905
CGD Leber hereditary optic neuropathy; Leber optic atrophy and dystonia; Mitochondrial complex I deficiency
Human Protein Atlas ENSG00000198886
IntAct P03905
PharmGKB PA31263
Reactome REACT_6305 (Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.)
UniProt P03905 Q6RL39 Q6RQN9 Q8HNR8

Target Cross References - Domain

InterPro IPR000260 (NADH_UbQ_OxRdtase_chain4_N.)
IPR001750 (NADH_UbQ/plastoQ_OxRdtase.)
IPR003918 (NADH_UbQ_OxRdtase.)
IPR010227 (NADH_Q_OxRdtase_chainM/4.)
Pfam PF00361 (Oxidored_q1)
PF01059 (Oxidored_q5_N)