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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4482
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PAK 4
Synonyms KIAA1142 | PAK-4 | PAK4 | Serine/threonine-protein kinase PAK 4 | p21-activated kinase 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase pakb subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 4 SINGLE PROTEIN O96013

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3128043 PF-03758309 Serine/threonine-protein kinase PAK 4 inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130669
Ensembl ENSG00000130669
GO Cellular Component GO:0005794 (Golgi apparatus)
GO:0005925 (focal adhesion)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0005524 (ATP binding)
GO:0048365 (Rac GTPase binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004672 (protein kinase activity)
GO Biological Process GO:0007346 (regulation of mitotic cell cycle)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0007266 (Rho protein signal transduction)
GO:0043408 (regulation of MAPK cascade)
GO:0030036 (actin cytoskeleton organization)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0006915 (apoptotic process)
GO:0032147 (activation of protein kinase activity)
GO:0006928 (movement of cell or subcellular component)
GO:0008283 (cell proliferation)
GO:0016049 (cell growth)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0016477 (cell migration)
GO:0042981 (regulation of apoptotic process)
Wikipedia PAK4

Target Cross References - Protein

canSAR O96013
Human Protein Atlas ENSG00000130669
IntAct O96013
Guide to Pharmacology 2136 (p21 protein (Cdc42/Rac)-activated kinase 4)
PharmGKB PA32920
UniProt Q9BU33 Q9ULS8 Q8NCH5 Q8NDE3 O96013 Q8N4E1 B4DGG6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR000095 (CRIB_dom.)
IPR011009 (Kinase-like_dom.)
Pfam PF00786 (PBD)
PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2OV2 4O0V 2X4Z 4JDH 4O0X 2J0I 4FIF 4FIH 2BVA 2CDZ 4FIG 4FII 4FIJ 4JDI 4L67 4APP 4JDJ 5BMS 2Q0N 4FIE 4JDK 4NJD 4O0Y
CREDO 2OV2 4O0V 2X4Z 4JDH 4O0X 2J0I 4FIF 4FIH 2BVA 2CDZ 4FIG 4FII 4FIJ 4JDI 4L67 4APP 4JDJ 5BMS 2Q0N 4FIE 4JDK 4NJD 4O0Y
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