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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4482
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PAK 4
Synonyms KIAA1142 | PAK-4 | PAK4 | Serine/threonine-protein kinase PAK 4 | p21-activated kinase 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase pakb subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 4 SINGLE PROTEIN O96013

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3128043 PF-03758309 Serine/threonine-protein kinase PAK 4 inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130669
Ensembl ENSG00000130669
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005913 (cell-cell adherens junction)
GO:0005925 (focal adhesion)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0098641 (cadherin binding involved in cell-cell adhesion)
GO Biological Process GO:0000278 (mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006928 (movement of cell or subcellular component)
GO:0007010 (cytoskeleton organization)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0008283 (cell proliferation)
GO:0016049 (cell growth)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0060996 (dendritic spine development)
GO:0071407 (cellular response to organic cyclic compound)
GO:0098609 (cell-cell adhesion)
Wikipedia PAK4

Target Cross References - Protein

canSAR O96013
Human Protein Atlas ENSG00000130669
IntAct O96013
Guide to Pharmacology 2136
Open Targets ENSG00000130669
PharmGKB PA32920
Pharos O96013 (Tchem)
Reactome R-HSA-428540 (Activation of Rac.)
UniProt B4DGG6 O96013 Q8N4E1 Q8NCH5 Q8NDE3 Q9BU33 Q9ULS8

Target Cross References - Domain

InterPro IPR000095 (CRIB_dom.)
IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR033923 (PAK_BD.)
Pfam PF00069 (Pkinase)
PF00786 (PBD)

Target Cross References - Structure

PDBe 2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU More...
CREDO 2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU More...
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