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Target Report Card

Target Name and Classification

Target ID CHEMBL4481
Preferred Name Nitric oxide synthase, inducible
Synonyms HEP-NOS | Hepatocyte NOS | Inducible NO synthase | Inducible NOS | NOS type II | NOS2 | NOS2A | Nitric oxide synthase, inducible | Peptidyl-cysteine S-nitrosylase NOS2 | iNOS
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Nitric oxide synthase, inducible SINGLE PROTEIN P35228

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111350 Nitric oxide synthase (inducible and endothelial) SELECTIVITY GROUP
CHEMBL2096621 Nitric oxide sythases; iNOS & nNOS SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000007171
Ensembl ENSG00000007171
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005777 (peroxisome)
GO:0005829 (cytosol)
GO:0030863 (cortical cytoskeleton)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0003958 (NADPH-hemoprotein reductase activity)
GO:0004517 (nitric-oxide synthase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0010181 (FMN binding)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0034617 (tetrahydrobiopterin binding)
GO:0034618 (arginine binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0050661 (NADP binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001912 (positive regulation of leukocyte mediated cytotoxicity)
GO:0002227 (innate immune response in mucosa)
GO:0006527 (arginine catabolic process)
GO:0006801 (superoxide metabolic process)
GO:0006809 (nitric oxide biosynthetic process)
GO:0007263 (nitric oxide mediated signal transduction)
GO:0007623 (circadian rhythm)
GO:0009617 (response to bacterium)
GO:0010629 (negative regulation of gene expression)
GO:0018119 (peptidyl-cysteine S-nitrosylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0031284 (positive regulation of guanylate cyclase activity)
GO:0032310 (prostaglandin secretion)
GO:0032496 (response to lipopolysaccharide)
GO:0035690 (cellular response to drug)
GO:0042127 (regulation of cell proliferation)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042742 (defense response to bacterium)
GO:0043457 (regulation of cellular respiration)
GO:0045454 (cell redox homeostasis)
GO:0045776 (negative regulation of blood pressure)
GO:0050796 (regulation of insulin secretion)
GO:0050829 (defense response to Gram-negative bacterium)
GO:0051712 (positive regulation of killing of cells of other organism)
GO:0055114 (oxidation-reduction process)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071346 (cellular response to interferon-gamma)
GO:0072604 (interleukin-6 secretion)
GO:0072606 (interleukin-8 secretion)
GO:0097755 (positive regulation of blood vessel diameter)
GO:1900015 (regulation of cytokine production involved in inflammatory response)
Wikipedia Nitric_oxide_synthase_2_(inducible)

Target Cross References - Protein

canSAR P35228
Human Protein Atlas ENSG00000007171
IntAct P35228
Guide to Pharmacology 1250
Open Targets ENSG00000007171
PharmGKB PA164724093
Reactome R-HSA-1222556 (ROS, RNS production in phagocytes.)
R-HSA-392154 (Nitric oxide stimulates guanylate cyclase.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt A1L3U5 B7ZLY2 O60757 O94994 P35228 Q16263 Q16692 Q4TTS5 Q9UD42

Target Cross References - Domain

InterPro IPR001094 (Flavdoxin-like.)
IPR001433 (OxRdtase_FAD/NAD-bd.)
IPR001709 (Flavoprot_Pyr_Nucl_cyt_Rdtase.)
IPR003097 (FAD-binding_1.)
IPR004030 (NOS_N.)
IPR008254 (Flavodoxin/NO_synth.)
IPR012144 (NOS_euk.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR017938 (Riboflavin_synthase-like_b-brl.)
IPR023173 (NADPH_Cyt_P450_Rdtase_alpha.)
IPR029039 (Flavoprotein-like_sf.)
IPR036119 (NOS_N_sf.)
Pfam PF00175 (NAD_binding_1)
PF00258 (Flavodoxin_1)
PF00667 (FAD_binding_1)
PF02898 (NO_synthase)

Target Cross References - Structure

PDBe 1NSI 2NSI 3E7G 3EJ8 3HR4 4CX7 4NOS 5XN3