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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4467
Target Type SINGLE PROTEIN
Preferred Name Mucosal addressin cell adhesion molecule-1
Synonyms MADCAM1 | MAdCAM-1 | Mucosal addressin cell adhesion molecule 1 | hMAdCAM-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • adhesion

Target Components

Component Description Relationship Accession
Mucosal addressin cell adhesion molecule 1 SINGLE PROTEIN Q13477

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109511 PF-00547659 Mucosal addressin cell adhesion molecule-1 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000099866
Ensembl ENSG00000099866
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0098640 (integrin binding involved in cell-matrix adhesion)
GO Biological Process GO:0002687 (positive regulation of leukocyte migration)
GO:0006955 (immune response)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007165 (signal transduction)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007568 (aging)
GO:0030198 (extracellular matrix organization)
GO:0034113 (heterotypic cell-cell adhesion)
GO:0043113 (receptor clustering)
GO:0050776 (regulation of immune response)
GO:0050901 (leukocyte tethering or rolling)
Wikipedia Addressin

Target Cross References - Protein

canSAR Q13477
Human Protein Atlas ENSG00000099866
IntAct Q13477
Open Targets ENSG00000099866
PharmGKB PA30522
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-216083 (Integrin cell surface interactions.)
UniProt A5PKV4 B2RPL9 O60222 O75867 Q13477 Q5UGI7

Target Cross References - Domain

InterPro IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR013783 (Ig-like_fold.)
IPR015169 (Adhes-Ig-like.)
Pfam PF09085 (Adhes-Ig_like)

Target Cross References - Structure

PDBe 1BQS 1GSM 4HBQ 4HC1 4HCR 4HD9
CREDO 1BQS 1GSM 4HBQ 4HC1 4HCR 4HD9
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