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Target Report Card

Target Name and Classification

Target ID CHEMBL4462
Preferred Name NAD-dependent deacetylase sirtuin 2
Synonyms NAD-dependent protein deacetylase sirtuin-2 | Regulatory protein SIR2 homolog 2 | SIR2-like protein 2 | SIR2L | SIR2L2 | SIRT2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iii

Target Components

Component Description Relationship Accession
NAD-dependent protein deacetylase sirtuin-2 SINGLE PROTEIN Q8IXJ6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000068903 ENSG00000283100
Ensembl ENSG00000068903 ENSG00000283100
GO Cellular Component GO:0000781 (chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005677 (chromatin silencing complex)
GO:0005694 (chromosome)
GO:0005720 (nuclear heterochromatin)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005813 (centrosome)
GO:0005814 (centriole)
GO:0005815 (microtubule organizing center)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030426 (growth cone)
GO:0030496 (midbody)
GO:0033010 (paranodal junction)
GO:0033270 (paranode region of axon)
GO:0042995 (cell projection)
GO:0043204 (perikaryon)
GO:0043209 (myelin sheath)
GO:0043219 (lateral loop)
GO:0043220 (Schmidt-Lanterman incisure)
GO:0044224 (juxtaparanode region of axon)
GO:0048471 (perinuclear region of cytoplasm)
GO:0072686 (mitotic spindle)
GO:0072687 (meiotic spindle)
GO:0097386 (glial cell projection)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0003950 (NAD+ ADP-ribosyltransferase activity)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0017136 (NAD-dependent histone deacetylase activity)
GO:0033558 (protein deacetylase activity)
GO:0034979 (NAD-dependent protein deacetylase activity)
GO:0035035 (histone acetyltransferase binding)
GO:0042826 (histone deacetylase binding)
GO:0042903 (tubulin deacetylase activity)
GO:0043130 (ubiquitin binding)
GO:0046872 (metal ion binding)
GO:0046970 (NAD-dependent histone deacetylase activity (H4-K16 specific))
GO:0070403 (NAD+ binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000183 (chromatin silencing at rDNA)
GO:0002376 (immune system process)
GO:0006342 (chromatin silencing)
GO:0006348 (chromatin silencing at telomere)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006471 (protein ADP-ribosylation)
GO:0006476 (protein deacetylation)
GO:0006914 (autophagy)
GO:0007049 (cell cycle)
GO:0007096 (regulation of exit from mitosis)
GO:0007399 (nervous system development)
GO:0008285 (negative regulation of cell proliferation)
GO:0010507 (negative regulation of autophagy)
GO:0010801 (negative regulation of peptidyl-threonine phosphorylation)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0016458 (gene silencing)
GO:0016575 (histone deacetylation)
GO:0021762 (substantia nigra development)
GO:0022011 (myelination in peripheral nervous system)
GO:0030154 (cell differentiation)
GO:0031641 (regulation of myelination)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0034599 (cellular response to oxidative stress)
GO:0034983 (peptidyl-lysine deacetylation)
GO:0035729 (cellular response to hepatocyte growth factor stimulus)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042325 (regulation of phosphorylation)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0043388 (positive regulation of DNA binding)
GO:0043491 (protein kinase B signaling)
GO:0044242 (cellular lipid catabolic process)
GO:0045087 (innate immune response)
GO:0045598 (regulation of fat cell differentiation)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045836 (positive regulation of meiotic nuclear division)
GO:0045843 (negative regulation of striated muscle tissue development)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048012 (hepatocyte growth factor receptor signaling pathway)
GO:0051301 (cell division)
GO:0051321 (meiotic cell cycle)
GO:0051726 (regulation of cell cycle)
GO:0051775 (response to redox state)
GO:0051781 (positive regulation of cell division)
GO:0051987 (positive regulation of attachment of spindle microtubules to kinetochore)
GO:0061428 (negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0061433 (cellular response to caloric restriction)
GO:0070446 (negative regulation of oligodendrocyte progenitor proliferation)
GO:0070932 (histone H3 deacetylation)
GO:0070933 (histone H4 deacetylation)
GO:0071219 (cellular response to molecule of bacterial origin)
GO:0071456 (cellular response to hypoxia)
GO:0071872 (cellular response to epinephrine stimulus)
GO:0090042 (tubulin deacetylation)
GO:1900119 (positive regulation of execution phase of apoptosis)
GO:1900195 (positive regulation of oocyte maturation)
GO:1900226 (negative regulation of NLRP3 inflammasome complex assembly)
GO:1900425 (negative regulation of defense response to bacterium)
GO:2000378 (negative regulation of reactive oxygen species metabolic process)
GO:2000777 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia)
Wikipedia SIRT2

Target Cross References - Protein

Human Protein Atlas ENSG00000068903 ENSG00000283100
IntAct Q8IXJ6
Guide to Pharmacology 2708
Open Targets ENSG00000068903 ENSG00000283100
PharmGKB PA35786
UniProt A8K3V1 B2RB45 O95889 Q8IXJ6 Q924Y7 Q9P0G8 Q9UNT0 Q9Y6E9 U5TP13

Target Cross References - Domain

InterPro IPR003000 (Sirtuin.)
IPR017328 (Sirtuin_class_I.)
IPR026590 (Ssirtuin_cat_dom.)
IPR026591 (Sirtuin_cat_small_dom_sf.)
IPR029035 (DHS-like_NAD/FAD-binding_dom.)
Pfam PF02146 (SIR2)

Target Cross References - Structure

PDBe 1J8F 3ZGO 3ZGV 4L3O 4R8M 4RMG 4RMH 4RMI 4RMJ 4X3O 4X3P 4Y6L 4Y6O 4Y6Q 5D7O 5D7P 5D7Q 5DY4 5DY5 5FYQ 5G4C 5MAR 5MAT 5Y5N
CREDO 1J8F 3ZGO 3ZGV 4L3O 4R8M 4RMG 4RMH 4RMI 4RMJ 4X3O 4X3P 4Y6L 4Y6O 4Y6Q 5D7O 5D7P 5D7Q 5DY4 5DY5 5FYQ 5G4C 5MAR 5MAT 5Y5N