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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4460
Target Type SINGLE PROTEIN
Preferred Name Serine racemase
Synonyms D-serine ammonia-lyase | D-serine dehydratase | L-serine ammonia-lyase | L-serine dehydratase | SRR | Serine racemase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Serine racemase SINGLE PROTEIN Q9GZT4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167720
Ensembl ENSG00000167720
GO Cellular Component GO:0005625 (soluble fraction)
GO:0005737 (cytoplasm)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003941 (L-serine ammonia-lyase activity)
GO:0005509 (calcium ion binding)
GO:0005524 (ATP binding)
GO:0008721 (D-serine ammonia-lyase activity)
GO:0016594 (glycine binding)
GO:0018114 (threonine racemase activity)
GO:0030165 (PDZ domain binding)
GO:0030170 (pyridoxal phosphate binding)
GO:0030378 (serine racemase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006563 (L-serine metabolic process)
GO:0032496 (response to lipopolysaccharide)
GO:0042866 (pyruvate biosynthetic process)
GO:0051289 (protein homotetramerization)
GO:0070179 (D-serine biosynthetic process)
Wikipedia Serine_racemase

Target Cross References - Protein

canSAR Q9GZT4
Human Protein Atlas ENSG00000167720
PharmGKB PA37877
UniProt D3DTI5 Q6IA55 Q9GZT4

Target Cross References - Domain

InterPro IPR000634 (Ser/Thr_deHydtase_PyrdxlP-BS.)
IPR001926 (PyrdxlP-dep_enz_bsu.)
Pfam PF00291 (PALP)

Target Cross References - Structure

PDBe 3L6B 3L6R
CREDO 3L6B 3L6R
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