ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4453
Target Type SINGLE PROTEIN
Preferred Name ETS domain protein Elk-1
Synonyms ELK1 | ETS domain-containing protein Elk-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
ETS domain-containing protein Elk-1 SINGLE PROTEIN P19419

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000126767
Ensembl ENSG00000126767
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043679 (axon terminus)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001047 (core promoter binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0009416 (response to light stimulus)
GO:0030154 (cell differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0071394 (cellular response to testosterone stimulus)
GO:0071396 (cellular response to lipid)
GO:0071480 (cellular response to gamma radiation)
GO:0071774 (response to fibroblast growth factor)
GO:1901216 (positive regulation of neuron death)
Wikipedia ELK1

Target Cross References - Protein

canSAR P19419
Human Protein Atlas ENSG00000126767
IntAct P19419
Open Targets ENSG00000126767
PharmGKB PA27749
Reactome R-HSA-198753 (ERK/MAPK targets.)
UniProt B2R7H4 O75606 O95058 P19419 Q969X8 Q9UJM4

Target Cross References - Domain

InterPro IPR000418 (Ets_dom.)
IPR011991 (WHTH_DNA-bd_dom.)
Pfam PF00178 (Ets)

Target Cross References - Structure

PDBe 1DUX
CREDO 1DUX
spacer
spacer