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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4446
Target Type SINGLE PROTEIN
Preferred Name Kallikrein 4
Synonyms EMSP1 | Enamel matrix serine proteinase 1 | KLK-L1 | KLK4 | Kallikrein-4 | Kallikrein-like protein 1 | PRSS17 | PSTS | Prostase | Serine protease 17
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Kallikrein-4 SINGLE PROTEIN Q9Y5K2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167749
Ensembl ENSG00000167749
GO Cellular Component GO:0005576 (extracellular region)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0031214 (biomineral tissue development)
GO:0097186 (amelogenesis)
Wikipedia KLK4

Target Cross References - Protein

CGD Amelogenesis imperfecta, type IIA1
Human Protein Atlas ENSG00000167749
IntAct Q9Y5K2
Guide to Pharmacology 2374
Open Targets ENSG00000167749
PharmGKB PA30154
UniProt Q4VB16 Q96RU5 Q9GZL6 Q9UBJ6 Q9Y5K2

Target Cross References - Domain

InterPro IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA
CREDO 2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA
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