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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4442
Target Type SINGLE PROTEIN
Preferred Name Cyclin-dependent kinase 3
Synonyms CDK3 | CDKN3 | Cell division protein kinase 3 | Cyclin-dependent kinase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdc2 subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 3 SINGLE PROTEIN Q00526

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111444 CDK3/cyclin E PROTEIN COMPLEX GROUP
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL3038471 CDK3/Cyclin E PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000250506
Ensembl ENSG00000250506
GO Cellular Component GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030332 (cyclin binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0010033 (response to organic substance)
GO:0010389 (regulation of G2/M transition of mitotic cell cycle)
GO:0010468 (regulation of gene expression)
GO:0016310 (phosphorylation)
GO:0045023 (G0 to G1 transition)
GO:0051301 (cell division)
Wikipedia Cyclin-dependent_kinase_3

Target Cross References - Protein

canSAR Q00526
Human Protein Atlas ENSG00000250506
IntAct Q00526
Guide to Pharmacology 1975
Open Targets ENSG00000250506
PharmGKB PA26309
Pharos Q00526 (Tchem)
UniProt Q00526

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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