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Target Report Card

Target Name and Classification

Target ID CHEMBL4441
Target Type SINGLE PROTEIN
Preferred Name C-X-C chemokine receptor type 3
Synonyms C-X-C chemokine receptor type 3 | CD_antigen=CD183 | CKR-L2 | CXC-R3 | CXCR-3 | CXCR3 | G protein-coupled receptor 9 | GPR9 | IP-10 receptor | Interferon-inducible protein 10 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cxc chemokine receptor

Target Components

Component Description Relationship Accession
C-X-C chemokine receptor type 3 SINGLE PROTEIN P49682

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186810
Ensembl ENSG00000186810
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0005515 (protein binding)
GO:0016494 (C-X-C chemokine receptor activity)
GO:0019956 (chemokine binding)
GO:0019958 (C-X-C chemokine binding)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001937 (negative regulation of endothelial cell proliferation)
GO:0002685 (regulation of leukocyte migration)
GO:0006915 (apoptotic process)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0008284 (positive regulation of cell proliferation)
GO:0010818 (T cell chemotaxis)
GO:0016525 (negative regulation of angiogenesis)
GO:0019722 (calcium-mediated signaling)
GO:0030816 (positive regulation of cAMP metabolic process)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0045766 (positive regulation of angiogenesis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050921 (positive regulation of chemotaxis)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0070098 (chemokine-mediated signaling pathway)
GO:0071954 (chemokine (C-C motif) ligand 11 production)
GO:1900118 (negative regulation of execution phase of apoptosis)
GO:1900119 (positive regulation of execution phase of apoptosis)
Wikipedia CXCR3

Target Cross References - Protein

canSAR P49682
Human Protein Atlas ENSG00000186810
IntAct P49682
Guide to Pharmacology 70
Open Targets ENSG00000186810
PharmGKB PA35049
Pharos P49682 (Tchem)
Reactome R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt B2R982 O15185 P49682 Q7Z710 Q9P2T4 Q9P2T5

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR004070 (Chemokine_CXCR3.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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