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Target Report Card

Target Name and Classification

Target ID CHEMBL4439
Target Type SINGLE PROTEIN
Preferred Name TGF-beta receptor type I
Synonyms ALK-5 | ALK5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta receptor type-1 | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TbetaR-I | Transforming growth factor-beta receptor type I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 1 subfamily

Target Components

Component Description Relationship Accession
TGF-beta receptor type-1 SINGLE PROTEIN P36897

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000106799
Ensembl ENSG00000106799
GO Molecular Function GO:0005025 (transforming growth factor beta receptor activity, type I)
GO:0005114 (type II transforming growth factor beta receptor binding)
GO:0005524 (ATP binding)
GO:0046872 (metal ion binding)
GO:0050431 (transforming growth factor beta binding)
GO:0070411 (I-SMAD binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0001822 (kidney development)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007507 (heart development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008354 (germ cell migration)
GO:0009952 (anterior/posterior pattern formation)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0030199 (collagen fibril organization)
GO:0030307 (positive regulation of cell growth)
GO:0045885 (positive regulation of survival gene product expression)
GO:0045893 (positive regulation of transcription, DNA-dependent)
GO:0048538 (thymus development)
GO:0048663 (neuron fate commitment)
GO:0048701 (embryonic cranial skeleton morphogenesis)
GO:0048844 (artery morphogenesis)
GO:0051272 (positive regulation of cellular component movement)
GO:0051897 (positive regulation of protein kinase B signaling cascade)
GO:0060017 (parathyroid gland development)
GO:0060021 (palate development)
GO:0060037 (pharyngeal system development)
GO:0060389 (pathway-restricted SMAD protein phosphorylation)
GO:0060391 (positive regulation of SMAD protein import into nucleus)
GO:0070723 (response to cholesterol)
Wikipedia TGF_beta_receptor_1

Target Cross References - Protein

canSAR P36897
CGD Loeys-Dietz syndrome, type 1A; Loeys-Dietz sydnrome, type 2A
Human Protein Atlas ENSG00000106799
IntAct P36897
Guide to Pharmacology 1788 (transforming growth factor, beta receptor 1)
PharmGKB PA36485
Reactome REACT_6844 (Signaling by TGF beta.)
UniProt P36897 Q6IR47 Q706C0 Q706C1

Target Cross References - Domain

InterPro IPR000472 (Activin_rcpt.)
IPR000719 (Prot_kinase_cat_dom.)
IPR003605 (TGF_beta_rcpt_GS.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF01064 (Activin_recp)
PF08515 (TGF_beta_GS)

Target Cross References - Structure

PDBe 1B6C 1IAS 1PY5 1RW8 1VJY 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD
CREDO 1B6C 1IAS 1PY5 1RW8 1VJY 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD
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