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Target Report Card

Target Name and Classification

Target ID CHEMBL4428
Target Type SINGLE PROTEIN
Preferred Name Prostaglandin I2 synthase
Synonyms CYP8 | CYP8A1 | PTGIS | Prostacyclin synthase | Prostaglandin I2 synthase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 8 > cytochrome p450 family 8a > cytochrome p450 8a1

Target Components

Component Description Relationship Accession
Prostacyclin synthase SINGLE PROTEIN Q16647

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124212
Ensembl ENSG00000124212
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0008116 (prostaglandin-I synthase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016853 (isomerase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006690 (icosanoid metabolic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006769 (nicotinamide metabolic process)
GO:0007566 (embryo implantation)
GO:0019371 (cyclooxygenase pathway)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0035360 (positive regulation of peroxisome proliferator activated receptor signaling pathway)
GO:0045019 (negative regulation of nitric oxide biosynthetic process)
GO:0045766 (positive regulation of angiogenesis)
GO:0046697 (decidualization)
GO:0050728 (negative regulation of inflammatory response)
GO:0055114 (oxidation-reduction process)
GO:0071347 (cellular response to interleukin-1)
GO:0071354 (cellular response to interleukin-6)
GO:0071456 (cellular response to hypoxia)
GO:0097190 (apoptotic signaling pathway)
GO:1900119 (positive regulation of execution phase of apoptosis)
Wikipedia Prostacyclin_synthase

Target Cross References - Protein

canSAR Q16647
Human Protein Atlas ENSG00000124212
Guide to Pharmacology 1356
Open Targets ENSG00000124212
PharmGKB PA292
Reactome R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193775 (Synthesis of bile acids and bile salts via 24-hydroxycholesterol.)
R-HSA-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-HSA-197264 (Nicotinamide salvaging.)
R-HSA-211979 (Eicosanoids.)
R-HSA-211994 (Sterols are 12-hydroxylated by CYP8B1.)
R-HSA-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
UniProt Q16647 Q3MII8 Q9HAX2 Q9HAX3 Q9HAX4

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002403 (Cyt_P450_E_grp-IV.)
IPR024204 (Cyt_P450_CYP7A1-type.)
IPR027286 (PTGIS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 2IAG 3B6H
CREDO 2IAG 3B6H
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