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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4427
Target Type SINGLE PROTEIN
Preferred Name Prostanoid DP receptor
Synonyms PGD receptor | PGD2 receptor | PTGDR | Prostaglandin D2 receptor | Prostanoid DP receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin D2 receptor SINGLE PROTEIN Q13258

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL426559 LAROPIPRANT Prostanoid DP receptor antagonist 3 Other PubMed
CHEMBL3545043 Asapiprant Prostanoid DP receptor antagonist 3 PubMed
CHEMBL1951575 VIDUPIPRANT Prostanoid DP receptor antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168229
Ensembl ENSG00000168229
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001785 (prostaglandin J receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004956 (prostaglandin D receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0030238 (male sex determination)
GO:0030431 (sleep)
GO:0046085 (adenosine metabolic process)
GO:0071799 (cellular response to prostaglandin D stimulus)
Wikipedia Prostaglandin_D2_receptor

Target Cross References - Protein

canSAR Q13258
Human Protein Atlas ENSG00000168229
Guide to Pharmacology 338
Open Targets ENSG00000168229
PharmGKB PA285
Pharos Q13258 (Tclin)
Reactome R-HSA-391908 (Prostanoid ligand receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt G3V5L3 Q13250 Q13251 Q13258 Q1ZZ52

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000376 (Pglndn_D_rcpt.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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