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Target Report Card

Target Name and Classification

Target ID CHEMBL4426
Target Type SINGLE PROTEIN
Preferred Name Phospholipase A2 group 1B
Synonyms Group IB phospholipase A2 | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phospholipase A2 SINGLE PROTEIN P04054

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170890
Ensembl ENSG00000170890
GO Cellular Component GO:0009986 (cell surface)
GO:0030141 (secretory granule)
GO:0005615 (extracellular space)
GO:0005576 (extracellular region)
GO Molecular Function GO:0005509 (calcium ion binding)
GO:0005102 (receptor binding)
GO:0032052 (bile acid binding)
GO:0004623 (phospholipase A2 activity)
GO:0047498 (calcium-dependent phospholipase A2 activity)
GO Biological Process GO:0006654 (phosphatidic acid biosynthetic process)
GO:0036152 (phosphatidylethanolamine acyl-chain remodeling)
GO:0050714 (positive regulation of protein secretion)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0006633 (fatty acid biosynthetic process)
GO:0007165 (signal transduction)
GO:0044281 (small molecule metabolic process)
GO:0045740 (positive regulation of DNA replication)
GO:0032431 (activation of phospholipase A2 activity)
GO:0032637 (interleukin-8 production)
GO:0035556 (intracellular signal transduction)
GO:0019370 (leukotriene biosynthetic process)
GO:0019731 (antibacterial humoral response)
GO:0036149 (phosphatidylinositol acyl-chain remodeling)
GO:0046474 (glycerophospholipid biosynthetic process)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0002227 (innate immune response in mucosa)
GO:0006644 (phospholipid metabolic process)
GO:0032869 (cellular response to insulin stimulus)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0000187 (activation of MAPK activity)
GO:0002446 (neutrophil mediated immunity)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0015758 (glucose transport)
GO:0036150 (phosphatidylserine acyl-chain remodeling)
GO:0046470 (phosphatidylcholine metabolic process)
GO:0007015 (actin filament organization)
GO:0030593 (neutrophil chemotaxis)
GO:0036148 (phosphatidylglycerol acyl-chain remodeling)
GO:0036151 (phosphatidylcholine acyl-chain remodeling)
GO:0044240 (multicellular organismal lipid catabolic process)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050482 (arachidonic acid secretion)
GO:0050778 (positive regulation of immune response)
Wikipedia PLA2G1B

Target Cross References - Protein

canSAR P04054
Human Protein Atlas ENSG00000170890
IntAct P04054
Guide to Pharmacology 1416 (sPLA2-1B)
PharmGKB PA33361
UniProt Q3KPI1 B2R4H5 P04054

Target Cross References - Domain

InterPro IPR016090 (PLipase_A2_dom.)
IPR013090 (PLipase_A2_AS.)
IPR001211 (PLipase_A2.)
Pfam PF00068 (Phospholip_A2_1)

Target Cross References - Structure

PDBe 3ELO
CREDO 3ELO
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