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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4425
Target Type SINGLE PROTEIN
Preferred Name Phosphodiesterase 1B
Synonyms 63 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDES1B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 1 > phosphodiesterase 1b

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B SINGLE PROTEIN Q01064

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY
CHEMBL2097161 Phosphodiesterase, PDE1/PDE5 PROTEIN FAMILY
CHEMBL2095150 Phosphodiesterase 1 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123360
Ensembl ENSG00000123360
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0004112 (cyclic-nucleotide phosphodiesterase activity)
GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity)
GO:0004117 (calmodulin-dependent cyclic-nucleotide phosphodiesterase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0047555 (3',5'-cyclic-GMP phosphodiesterase activity)
GO:0048101 (calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity)
GO Biological Process GO:0001505 (regulation of neurotransmitter levels)
GO:0001975 (response to amphetamine)
GO:0006198 (cAMP catabolic process)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007626 (locomotory behavior)
GO:0008542 (visual learning)
GO:0030224 (monocyte differentiation)
GO:0036006 (cellular response to macrophage colony-stimulating factor stimulus)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042428 (serotonin metabolic process)
GO:0046069 (cGMP catabolic process)
GO:0097011 (cellular response to granulocyte macrophage colony-stimulating factor stimulus)
Wikipedia PDE1B

Target Cross References - Protein

canSAR Q01064
Human Protein Atlas ENSG00000123360
IntAct Q01064
Guide to Pharmacology 1295
Open Targets ENSG00000123360
PharmGKB PA33123
Reactome R-HSA-111957 (Cam-PDE 1 activation.)
R-HSA-418457 (cGMP effects.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt Q01064 Q92825 Q96KP3

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR013706 (PDEase_N.)
IPR023088 (PDEase.)
IPR023174 (PDEase_CS.)
Pfam PF00233 (PDEase_I)
PF08499 (PDEase_I_N)

Target Cross References - Structure

PDBe 1TAZ 4NPV 4NPW 5B25
CREDO 1TAZ 4NPV 4NPW 5B25
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