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Target Report Card

Target Name and Classification

Target ID CHEMBL4423
Preferred Name C-C chemokine receptor type 6
Synonyms C-C CKR-6 | C-C chemokine receptor type 6 | CC-CKR-6 | CCR-6 | CCR6 | CD_antigen=CD196 | CKR-L3 | CKRL3 | CMKBR6 | Chemokine receptor-like 3 | DRY6 | G-protein coupled receptor 29 | GPR-CY4 | GPR29 | GPRCY4 | LARC receptor | STRL22
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 6 SINGLE PROTEIN P51684

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112486
Ensembl ENSG00000112486
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0036126 (sperm flagellum)
GO:0097225 (sperm midpiece)
GO:0097228 (sperm principal piece)
GO:0097524 (sperm plasma membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0005515 (protein binding)
GO:0016493 (C-C chemokine receptor activity)
GO:0019957 (C-C chemokine binding)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0002407 (dendritic cell chemotaxis)
GO:0002523 (leukocyte migration involved in inflammatory response)
GO:0006935 (chemotaxis)
GO:0006955 (immune response)
GO:0006959 (humoral immune response)
GO:0006968 (cellular defense response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0019722 (calcium-mediated signaling)
GO:0048290 (isotype switching to IgA isotypes)
GO:0060326 (cell chemotaxis)
GO:0060474 (positive regulation of flagellated sperm motility involved in capacitation)
GO:0070098 (chemokine-mediated signaling pathway)
GO:0072676 (lymphocyte migration)
GO:0072678 (T cell migration)
GO:0072679 (thymocyte migration)
GO:1904155 (DN2 thymocyte differentiation)
GO:1904156 (DN3 thymocyte differentiation)
GO:2000404 (regulation of T cell migration)
GO:2000510 (positive regulation of dendritic cell chemotaxis)
Wikipedia C-C_chemokine_receptor_type_6

Target Cross References - Protein

canSAR P51684
Human Protein Atlas ENSG00000112486
Guide to Pharmacology 63
Open Targets ENSG00000112486
PharmGKB PA26171
Pharos P51684 (Tchem)
Reactome R-HSA-1461957 (Beta defensins.)
R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt E1P5C6 P51684 P78553 Q92846

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR004067 (Chemokine_CCR6.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)