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Target Report Card

Target Name and Classification

Target ID CHEMBL4403
Preferred Name Ryanodine receptor 2
Synonyms Cardiac muscle ryanodine receptor | Cardiac muscle ryanodine receptor-calcium release channel | RYR-2 | RYR2 | RyR2 | Ryanodine receptor 2 | Type 2 ryanodine receptor | hRYR-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ryanodine receptor

Target Components

Component Description Relationship Accession
Ryanodine receptor 2 SINGLE PROTEIN Q92736

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198626
Ensembl ENSG00000198626
GO Cellular Component GO:0005790 (smooth endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0014701 (junctional sarcoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0030017 (sarcomere)
GO:0030018 (Z disc)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0034704 (calcium channel complex)
GO:0043234 (protein complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005219 (ryanodine-sensitive calcium-release channel activity)
GO:0005262 (calcium channel activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0015278 (calcium-release channel activity)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0034236 (protein kinase A catalytic subunit binding)
GO:0034237 (protein kinase A regulatory subunit binding)
GO:0042802 (identical protein binding)
GO:0043621 (protein self-association)
GO:0043924 (suramin binding)
GO:0044325 (ion channel binding)
GO:0048763 (calcium-induced calcium release activity)
GO:0097159 (organic cyclic compound binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0002027 (regulation of heart rate)
GO:0003143 (embryonic heart tube morphogenesis)
GO:0003220 (left ventricular cardiac muscle tissue morphogenesis)
GO:0003300 (cardiac muscle hypertrophy)
GO:0005513 (detection of calcium ion)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007275 (multicellular organism development)
GO:0010460 (positive regulation of heart rate)
GO:0010881 (regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)
GO:0010882 (regulation of cardiac muscle contraction by calcium ion signaling)
GO:0014808 (release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
GO:0014850 (response to muscle activity)
GO:0019722 (calcium-mediated signaling)
GO:0030509 (BMP signaling pathway)
GO:0031000 (response to caffeine)
GO:0034220 (ion transmembrane transport)
GO:0035584 (calcium-mediated signaling using intracellular calcium source)
GO:0035994 (response to muscle stretch)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051284 (positive regulation of sequestering of calcium ion)
GO:0051480 (regulation of cytosolic calcium ion concentration)
GO:0051775 (response to redox state)
GO:0055085 (transmembrane transport)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0060048 (cardiac muscle contraction)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060401 (cytosolic calcium ion transport)
GO:0060402 (calcium ion transport into cytosol)
GO:0070296 (sarcoplasmic reticulum calcium ion transport)
GO:0070588 (calcium ion transmembrane transport)
GO:0071313 (cellular response to caffeine)
GO:0071872 (cellular response to epinephrine stimulus)
GO:0072599 (establishment of protein localization to endoplasmic reticulum)
GO:0086005 (ventricular cardiac muscle cell action potential)
GO:0086029 (Purkinje myocyte to ventricular cardiac muscle cell signaling)
GO:0086064 (cell communication by electrical coupling involved in cardiac conduction)
GO:0097050 (type B pancreatic cell apoptotic process)
GO:0098735 (positive regulation of the force of heart contraction)
GO:0098904 (regulation of AV node cell action potential)
GO:0098907 (regulation of SA node cell action potential)
GO:0098910 (regulation of atrial cardiac muscle cell action potential)
GO:0098911 (regulation of ventricular cardiac muscle cell action potential)
GO:1901896 (positive regulation of calcium-transporting ATPase activity)
GO:1903779 (regulation of cardiac conduction)
Wikipedia Ryanodine_receptor_2

Target Cross References - Protein

CGD Ventricular tachycardia, catecholaminergic polymorphic, 1; Arrhythmogenic right ventricular dysplasia 2
Human Protein Atlas ENSG00000198626
IntAct Q92736
Guide to Pharmacology 748
Open Targets ENSG00000198626
Pharos Q92736 (Tclin)
Reactome R-HSA-2672351 (Stimuli-sensing channels.)
R-HSA-5578775 (Ion homeostasis.)
UniProt Q15411 Q546N8 Q5T3P2 Q92736

Target Cross References - Domain

InterPro IPR000699 (RIH_dom.)
IPR001870 (B30.2/SPRY.)
IPR002048 (EF_hand_dom.)
IPR003032 (Ryanodine_rcpt.)
IPR003877 (SPRY_dom.)
IPR005821 (Ion_trans_dom.)
IPR009460 (Ryanrecept_TM4-6.)
IPR011992 (EF-hand-dom_pair.)
IPR013320 (ConA-like_dom.)
IPR013333 (Ryan_recept.)
IPR013662 (RIH_assoc-dom.)
IPR014821 (Ins145_P3_rcpt.)
IPR015925 (Ryanodine_recept-rel.)
IPR016093 (MIR_motif.)
Pfam PF00520 (Ion_trans)
PF00622 (SPRY)
PF02026 (RyR)
PF02815 (MIR)
PF06459 (RR_TM4-6)
PF08454 (RIH_assoc)
PF08709 (Ins145_P3_rec)
PF13833 (EF-hand_8)

Target Cross References - Structure