ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4394
Preferred Name Sphingosine kinase 1
Synonyms SK 1 | SPHK | SPHK1 | SPK 1 | SPK | Sphingosine kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Sphingosine kinase 1 SINGLE PROTEIN Q9NYA1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176170
Ensembl ENSG00000176170
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0030424 (axon)
GO:0043005 (neuron projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0003677 (DNA binding)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0008481 (sphinganine kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017050 (D-erythro-sphingosine kinase activity)
GO:0038036 (sphingosine-1-phosphate receptor activity)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0001568 (blood vessel development)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001956 (positive regulation of neurotransmitter secretion)
GO:0003376 (sphingosine-1-phosphate signaling pathway)
GO:0006457 (protein folding)
GO:0006670 (sphingosine metabolic process)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007420 (brain development)
GO:0007565 (female pregnancy)
GO:0008284 (positive regulation of cell proliferation)
GO:0009267 (cellular response to starvation)
GO:0010800 (positive regulation of peptidyl-threonine phosphorylation)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0010976 (positive regulation of neuron projection development)
GO:0014070 (response to organic cyclic compound)
GO:0014075 (response to amine)
GO:0019371 (cyclooxygenase pathway)
GO:0019722 (calcium-mediated signaling)
GO:0030148 (sphingolipid biosynthetic process)
GO:0030307 (positive regulation of cell growth)
GO:0030335 (positive regulation of cell migration)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0032026 (response to magnesium ion)
GO:0032570 (response to progesterone)
GO:0032651 (regulation of interleukin-1 beta production)
GO:0033198 (response to ATP)
GO:0035556 (intracellular signal transduction)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0043066 (negative regulation of apoptotic process)
GO:0045766 (positive regulation of angiogenesis)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046512 (sphingosine biosynthetic process)
GO:0046521 (sphingoid catabolic process)
GO:0046834 (lipid phosphorylation)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070555 (response to interleukin-1)
GO:0071363 (cellular response to growth factor stimulus)
Wikipedia Sphingosine_kinase_1

Target Cross References - Protein

Human Protein Atlas ENSG00000176170
IntAct Q9NYA1
Guide to Pharmacology 2204
Open Targets ENSG00000176170
PharmGKB PA36070
Pharos Q9NYA1 (Tchem)
Reactome R-HSA-1660661 (Sphingolipid de novo biosynthesis.)
R-HSA-390471 (Association of TriC/CCT with target proteins during biosynthesis.)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
UniProt Q8N632 Q96GK1 Q9HD92 Q9NY70 Q9NYA1 Q9NYL3

Target Cross References - Domain

InterPro IPR001206 (Diacylglycerol_kinase_cat_dom.)
IPR016064 (NAD/diacylglycerol_kinase.)
Pfam PF00781 (DAGK_cat)

Target Cross References - Structure

PDBe 3VZB 3VZC 3VZD 4L02 4V24