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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4393
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase 12
Synonyms HME | ME | MME | MMP-12 | MMP12 | Macrophage elastase | Macrophage metalloelastase | Matrix metalloproteinase-12 | hME
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Macrophage metalloelastase SINGLE PROTEIN P39900

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000262406
Ensembl ENSG00000262406
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0031012 (extracellular matrix)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0014070 (response to organic cyclic compound)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0035313 (wound healing, spreading of epidermal cells)
GO:0042060 (wound healing)
GO:0042493 (response to drug)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0060054 (positive regulation of epithelial cell proliferation involved in wound healing)
Wikipedia Matrix_metallopeptidase_12

Target Cross References - Protein

canSAR P39900
Human Protein Atlas ENSG00000262406
IntAct P39900
Guide to Pharmacology 1636
Open Targets ENSG00000262406
PharmGKB PA30870
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
UniProt B2R9X8 B7ZLF6 P39900 Q2M1L9

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR016293 (Pept_M10A_stromelysin-type.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom.)
IPR028718 (MMP12.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)

Target Cross References - Structure

PDBe 1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 2HU6 2OXU 2OXW 2OXZ 2W0D 2WO8 2WO9 2WOA 3BA0 3EHX 3EHY 3F15 3F16 3F17 3F18 More...
CREDO 1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 2HU6 2OXU 2OXW 2OXZ 2W0D 2WO8 2WO9 2WOA 3BA0 3EHX 3EHY 3F15 3F16 3F17 3F18 More...
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