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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4390
Target Type SINGLE PROTEIN
Preferred Name Excitatory amino acid transporter 5
Synonyms EAAT5 | Excitatory amino acid transporter 5 | Retinal glutamate transporter | SLC1A7 | Solute carrier family 1 member 7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc01 family of amino acid transporters

Target Components

Component Description Relationship Accession
Excitatory amino acid transporter 5 SINGLE PROTEIN O00341

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162383
Ensembl ENSG00000162383
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0005314 (high-affinity glutamate transmembrane transporter activity)
GO:0017153 (sodium:dicarboxylate symporter activity)
Wikipedia Excitatory_amino-acid_transporter_5

Target Cross References - Protein

canSAR O00341
Human Protein Atlas ENSG00000162383
Guide to Pharmacology 872 (Excitatory amino acid transporter 5)
PharmGKB PA35832
Reactome REACT_13685 (Synaptic Transmission.)
REACT_15518 (Transmembrane transport of small molecules.)
REACT_19419 (Amino acid and oligopeptide SLC transporters.)
UniProt O00341 Q5VVZ0 Q969Z8

Target Cross References - Domain

InterPro IPR001991 (Na-dicarboxylate_symporter.)
IPR018107 (Na-dicarboxylate_symporter_CS.)
Pfam PF00375 (SDF)
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