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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4388
Preferred Name Thymidylate kinase
Synonyms CDC8 | DTYMK | TMPK | TYMK | Thymidylate kinase | dTMP kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Thymidylate kinase SINGLE PROTEIN P23919

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168393
Ensembl ENSG00000168393
GO Cellular Component GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005758 (mitochondrial intermembrane space)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004798 (thymidylate kinase activity)
GO:0005524 (ATP binding)
GO:0009041 (uridylate kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0050145 (nucleoside phosphate kinase activity)
GO Biological Process GO:0006227 (dUDP biosynthetic process)
GO:0006233 (dTDP biosynthetic process)
GO:0006235 (dTTP biosynthetic process)
GO:0007049 (cell cycle)
GO:0008283 (cell proliferation)
GO:0009165 (nucleotide biosynthetic process)
GO:0015949 (nucleobase-containing small molecule interconversion)
GO:0016310 (phosphorylation)
GO:0043627 (response to estrogen)
GO:0045445 (myoblast differentiation)
GO:0046686 (response to cadmium ion)
GO:0046939 (nucleotide phosphorylation)
GO:0046940 (nucleoside monophosphate phosphorylation)
GO:0071363 (cellular response to growth factor stimulus)
Wikipedia DTYMK

Target Cross References - Protein

canSAR P23919
Human Protein Atlas ENSG00000168393
IntAct P23919
Open Targets ENSG00000168393
PharmGKB PA150
Pharos P23919 (Tbio)
Reactome R-HSA-499943 (Synthesis and interconversion of nucleotide di- and triphosphates.)
UniProt B7ZW70 P23919 Q6FGX1 Q9BUX4

Target Cross References - Domain

InterPro IPR018094 (Thymidylate_kinase.)
IPR018095 (Thymidylate_kin_CS.)
IPR027417 (P-loop_NTPase.)

Target Cross References - Structure

PDBe 1E2D 1E2E 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1NMX 1NMY 1NMZ 1NN0 1NN1 1NN3 1NN5 2XX3
CREDO 1E2D 1E2E 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1NMX 1NMY 1NMZ 1NN0 1NN1 1NN3 1NN5 2XX3