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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4382
Target Type SINGLE PROTEIN
Preferred Name Transcription factor E2F1
Synonyms E2F-1 | E2F1 | PBR3 | RBAP-1 | RBBP-3 | RBBP3 | Retinoblastoma-associated protein 1 | Retinoblastoma-binding protein 3 | Transcription factor E2F1 | pRB-binding protein E2F-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Transcription factor E2F1 SINGLE PROTEIN Q01094

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101412
Ensembl ENSG00000101412
GO Cellular Component GO:0005739 (mitochondrion)
GO:0035189 (Rb-E2F complex)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003714 (transcription corepressor activity)
GO:0008134 (transcription factor binding)
GO:0016563 (transcription activator activity)
GO:0016566 (specific transcriptional repressor activity)
GO Biological Process GO:0000080 (G1 phase of mitotic cell cycle)
GO:0000085 (G2 phase of mitotic cell cycle)
GO:0006915 (apoptosis)
GO:0008283 (cell proliferation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048255 (mRNA stabilization)
GO:0071930 (negative regulation of transcription involved in G1/S phase of mitotic cell cycle)
GO:2000045 (regulation of G1/S transition of mitotic cell cycle)
Wikipedia E2F1

Target Cross References - Protein

canSAR Q01094
Human Protein Atlas ENSG00000101412
IntAct Q01094
PharmGKB PA152
Reactome REACT_152 (Cell Cycle, Mitotic.)
UniProt Q01094 Q13143 Q92768

Target Cross References - Domain

InterPro IPR003316 (E2F_TDP.)
IPR011991 (WHTH_trsnscrt_rep_DNA-bd.)
IPR015633 (E2F.)
IPR015634 (Transcription_factor_E2F1.)
Pfam PF02319 (E2F_TDP)

Target Cross References - Structure

PDBe 1H24 1O9K 2AZE
CREDO 1H24 1O9K 2AZE
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