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Target Report Card

Target Name and Classification

Target ID CHEMBL4382
Preferred Name Transcription factor E2F1
Synonyms E2F-1 | E2F1 | PBR3 | RBAP-1 | RBBP-3 | RBBP3 | Retinoblastoma-associated protein 1 | Retinoblastoma-binding protein 3 | Transcription factor E2F1 | pRB-binding protein E2F-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Transcription factor E2F1 SINGLE PROTEIN Q01094

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101412
Ensembl ENSG00000101412
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005813 (centrosome)
GO:0032991 (macromolecular complex)
GO:0035189 (Rb-E2F complex)
GO Molecular Function GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001047 (core promoter binding)
GO:0001227 (transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019901 (protein kinase binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0000077 (DNA damage checkpoint)
GO:0000083 (regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006915 (apoptotic process)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007049 (cell cycle)
GO:0007283 (spermatogenesis)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0010628 (positive regulation of gene expression)
GO:0030900 (forebrain development)
GO:0043065 (positive regulation of apoptotic process)
GO:0043276 (anoikis)
GO:0043392 (negative regulation of DNA binding)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048255 (mRNA stabilization)
GO:0051726 (regulation of cell cycle)
GO:0070317 (negative regulation of G0 to G1 transition)
GO:0070345 (negative regulation of fat cell proliferation)
GO:0071398 (cellular response to fatty acid)
GO:0071456 (cellular response to hypoxia)
GO:0071466 (cellular response to xenobiotic stimulus)
GO:0071930 (negative regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator)
GO:1900740 (positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)
GO:1990086 (lens fiber cell apoptotic process)
GO:1990090 (cellular response to nerve growth factor stimulus)
GO:2000045 (regulation of G1/S transition of mitotic cell cycle)
Wikipedia E2F1

Target Cross References - Protein

canSAR Q01094
Human Protein Atlas ENSG00000101412
IntAct Q01094
Open Targets ENSG00000101412
PharmGKB PA152
Reactome R-HSA-111448 (Activation of NOXA and translocation to mitochondria.)
R-HSA-113501 (Inhibition of replication initiation of damaged DNA by RB1/E2F1.)
R-HSA-1362277 (Transcription of E2F targets under negative control by DREAM complex.)
R-HSA-1362300 (Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.)
R-HSA-139915 (Activation of PUMA and translocation to mitochondria.)
R-HSA-1912408 (Pre-NOTCH Transcription and Translation.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2559585 (Oncogene Induced Senescence.)
R-HSA-539107 (Activation of E2F1 target genes at G1/S.)
R-HSA-6804116 (TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.)
R-HSA-68689 (CDC6 association with the ORC:origin complex.)
R-HSA-68911 (G2 Phase.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-69298 (Association of licensing factors with the pre-replicative complex.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
R-HSA-8953750 (Transcriptional Regulation by E2F6.)
UniProt Q01094 Q13143 Q92768

Target Cross References - Domain

InterPro IPR003316 (E2F_WHTH_DNA-bd_dom.)
IPR015633 (E2F.)
IPR032198 (E2F_CC-MB.)
IPR036388 (WH-like_DNA-bd_sf.)
IPR036390 (WH_DNA-bd_sf.)
IPR037241 (E2F-DP_heterodim.)
Pfam PF02319 (E2F_TDP)
PF16421 (E2F_CC-MB)

Target Cross References - Structure

PDBe 1H24 1O9K 2AZE 5M9N 5M9O
CREDO 1H24 1O9K 2AZE 5M9N 5M9O