ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4377
Preferred Name Guanine nucleotide-binding protein G(s), subunit alpha
Synonyms Adenylate cyclase-stimulating G alpha protein | GNAS | GNAS1 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other membrane protein

Target Components

Component Description Relationship Accession
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short SINGLE PROTEIN P63092

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087460
Ensembl ENSG00000087460
GO Cellular Component GO:0005834 (heterotrimeric G-protein complex)
GO:0031224 (intrinsic to membrane)
GO:0032588 (trans-Golgi network membrane)
GO Molecular Function GO:0003924 (GTPase activity)
GO:0004016 (adenylate cyclase activity)
GO:0004871 (signal transducer activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0005525 (GTP binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006112 (energy reserve metabolic process)
GO:0006833 (water transport)
GO:0007186 (G-protein coupled receptor protein signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007608 (sensory perception of smell)
GO:0030168 (platelet activation)
GO:0046907 (intracellular transport)
GO:0050796 (regulation of insulin secretion)
GO:0055085 (transmembrane transport)
GO:0071377 (cellular response to glucagon stimulus)
Wikipedia GNAS_complex_locus

Target Cross References - Protein

canSAR P63092
CGD Pseudohypoparathyroidism, type IA; Pseudohypoparathyroidism, type IB; Pseudohypoparathyroidism, type IC; Progressive osseous heteroplasia; McCune-Albright syndrome
Human Protein Atlas ENSG00000087460
IntAct P63092
PharmGKB PA175
Reactome REACT_14797 (Signaling by GPCR.)
REACT_1505 (Integration of energy metabolism.)
REACT_15380 (Diabetes pathways.)
REACT_15518 (Transmembrane transport of small molecules.)
REACT_604 (Hemostasis.)
UniProt E1P5G5 P04895 P63092 Q12927 Q14433 Q32P26 Q5JWD2 Q5JWD4 Q5JWD5 Q6NR75 Q6NXS0 Q8TBC0 Q96H70

Target Cross References - Domain

InterPro IPR000367 (Gprotein_alpha_S.)
IPR001019 (Gprotein_alpha_su.)
IPR011025 (GproteinA_insert.)
Pfam PF00503 (G-alpha)