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Target Report Card

Target Name and Classification

Target ID CHEMBL4377
Preferred Name Guanine nucleotide-binding protein G(s), subunit alpha
Synonyms Adenylate cyclase-stimulating G alpha protein | GNAS | GNAS1 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other membrane protein

Target Components

Component Description Relationship Accession
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short SINGLE PROTEIN P63092

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000087460
Ensembl ENSG00000087460
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005834 (heterotrimeric G-protein complex)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031224 (intrinsic component of membrane)
GO:0032588 (trans-Golgi network membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0019001 (guanyl nucleotide binding)
GO:0031683 (G-protein beta/gamma-subunit complex binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0003091 (renal water homeostasis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007608 (sensory perception of smell)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0043547 (positive regulation of GTPase activity)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0046907 (intracellular transport)
GO:0048589 (developmental growth)
GO:0050796 (regulation of insulin secretion)
GO:0050890 (cognition)
GO:0060348 (bone development)
GO:0060789 (hair follicle placode formation)
GO:0070527 (platelet aggregation)
GO:0071377 (cellular response to glucagon stimulus)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:0071870 (cellular response to catecholamine stimulus)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
Wikipedia GNAS_complex_locus

Target Cross References - Protein

canSAR P63092
CGD Pseudohypoparathyroidism, type IA; Pseudohypoparathyroidism, type IB; Pseudohypoparathyroidism, type IC; Progressive osseous heteroplasia; McCune-Albright syndrome
Human Protein Atlas ENSG00000087460
IntAct P63092
Open Targets ENSG00000087460
PharmGKB PA175
Reactome R-HSA-163359 (Glucagon signaling in metabolic regulation.)
R-HSA-164378 (PKA activation in glucagon signalling.)
R-HSA-381676 (Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.)
R-HSA-392851 (Prostacyclin signalling through prostacyclin receptor.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-418597 (G alpha (z) signalling events.)
R-HSA-420092 (Glucagon-type ligand receptors.)
R-HSA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-HSA-5610787 (Hedgehog 'off' state.)
UniProt A6NI00 E1P5G5 P04895 P63092 Q12927 Q14433 Q32P26 Q5JWD2 Q5JWD4 Q5JWD5 Q6NR75 Q6NXS0 Q8TBC0 Q96H70

Target Cross References - Domain

InterPro IPR000367 (Gprotein_alpha_S.)
IPR001019 (Gprotein_alpha_su.)
IPR011025 (GproteinA_insert.)
IPR027417 (P-loop_NTPase.)
Pfam PF00503 (G-alpha)

Target Cross References - Structure

PDBe 5G53