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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4375
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase SRPK1
Synonyms SFRS protein kinase 1 | SR-protein-specific kinase 1 | SRPK1 | SRSF protein kinase 1 | Serine/arginine-rich protein-specific kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase srpk family

Target Components

Component Description Relationship Accession
SRSF protein kinase 1 SINGLE PROTEIN Q96SB4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000096063
Ensembl ENSG00000096063
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0016363 (nuclear matrix)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0006397 (mRNA processing)
GO:0006468 (protein phosphorylation)
GO:0007059 (chromosome segregation)
GO:0008380 (RNA splicing)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0035092 (sperm chromatin condensation)
GO:0035556 (intracellular signal transduction)
GO:0045070 (positive regulation of viral genome replication)
GO:0045071 (negative regulation of viral genome replication)
GO:0045087 (innate immune response)
GO:0048024 (regulation of mRNA splicing, via spliceosome)
GO:0050684 (regulation of mRNA processing)
Wikipedia SRPK1

Target Cross References - Protein

canSAR Q96SB4
Human Protein Atlas ENSG00000096063
IntAct Q96SB4
Guide to Pharmacology 2208
Open Targets ENSG00000096063
PharmGKB PA36129
Pharos Q96SB4 (Tchem)
UniProt B4DS61 Q12890 Q5R364 Q5R365 Q8IY12 Q96SB4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1WAK 1WBP 3BEG 4WUA
CREDO 1WAK 1WBP 3BEG 4WUA
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