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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4374
Preferred Name Photoreceptor-specific nuclear receptor
Synonyms NR2E3 | Nuclear receptor subfamily 2 group E member 3 | PNR | Photoreceptor-specific nuclear receptor | RNR | Retina-specific nuclear receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group e > nuclear hormone receptor subfamily 2 group e member 3

Target Components

Component Description Relationship Accession
Photoreceptor-specific nuclear receptor SINGLE PROTEIN Q9Y5X4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000031544
Ensembl ENSG00000031544
GO Cellular Component GO:0005654 (nucleoplasm)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0005496 (steroid binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0006366 (transcription from RNA polymerase II promoter)
GO:0007601 (visual perception)
GO:0007602 (phototransduction)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
Wikipedia Photoreceptor_cell-specific_nuclear_receptor

Target Cross References - Protein

canSAR Q9Y5X4
CGD Enhanced S-cone syndrome; Retinitis pigmentosa 37
Human Protein Atlas ENSG00000031544
Guide to Pharmacology 616 (PNR)
PharmGKB PA31757
Reactome REACT_71 (Gene Expression.)
UniProt Q9UHM4 Q9Y5X4

Target Cross References - Domain

InterPro IPR000003 (Retinoid-X_rcpt.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)