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Target Report Card

Target Name and Classification

Target ID CHEMBL4367
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase TXK
Synonyms PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | Tyrosine-protein kinase TXK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase tec family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase TXK SINGLE PROTEIN P42681

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074966
Ensembl ENSG00000074966
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001012 (RNA polymerase II regulatory region DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0001816 (cytokine production)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007229 (integrin-mediated signaling pathway)
GO:0010543 (regulation of platelet activation)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0042246 (tissue regeneration)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046777 (protein autophosphorylation)
GO:0050852 (T cell receptor signaling pathway)
GO:0060335 (positive regulation of interferon-gamma-mediated signaling pathway)
Wikipedia TXK_(gene)

Target Cross References - Protein

canSAR P42681
Human Protein Atlas ENSG00000074966
IntAct P42681
Guide to Pharmacology 2268
Open Targets ENSG00000074966
PharmGKB PA37090
Pharos P42681 (Tchem)
Reactome R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
UniProt P42681 Q14220

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
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