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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4361
Target Type SINGLE PROTEIN
Preferred Name Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms BCL2L3 | Bcl-2-like protein 3 | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 | mcl1/EAT
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Induced myeloid leukemia cell differentiation protein Mcl-1 SINGLE PROTEIN Q07820

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143384
Ensembl ENSG00000143384
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005741 (mitochondrial outer membrane)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0005515 (protein binding)
GO:0015266 (protein channel activity)
GO:0046982 (protein heterodimerization activity)
GO:0051434 (BH3 domain binding)
GO Biological Process GO:0001709 (cell fate determination)
GO:0006915 (apoptosis)
GO:0006916 (anti-apoptosis)
GO:0007275 (multicellular organismal development)
GO:0019725 (cellular homeostasis)
GO:0034097 (response to cytokine stimulus)
Wikipedia MCL1

Target Cross References - Protein

canSAR Q07820
Human Protein Atlas ENSG00000143384
IntAct Q07820
PharmGKB PA30688
UniProt B2R6B2 D3DV03 D3DV04 Q07820 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1

Target Cross References - Domain

InterPro IPR000712 (Bcl2_BH.)
IPR002475 (Bcl2-like_apoptosis.)
IPR013281 (Apop_reg_Mc1.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR020728 (Bcl2_BH3_motif_CS.)
Pfam PF00452 (Bcl-2)

Target Cross References - Structure

PDBe 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1
CREDO 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1
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