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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4361
Target Type SINGLE PROTEIN
Preferred Name Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms BCL2L3 | Bcl-2-like protein 3 | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 | mcl1/EAT
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Induced myeloid leukemia cell differentiation protein Mcl-1 SINGLE PROTEIN Q07820

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107358 OBATOCLAX MESYLATE Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor 3 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143384
Ensembl ENSG00000143384
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0097136 (Bcl-2 family protein complex)
GO Molecular Function GO:0005515 (protein binding)
GO:0015266 (protein channel activity)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0051434 (BH3 domain binding)
GO Biological Process GO:0001709 (cell fate determination)
GO:0006915 (apoptotic process)
GO:0007275 (multicellular organism development)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0008637 (apoptotic mitochondrial changes)
GO:0019725 (cellular homeostasis)
GO:0030154 (cell differentiation)
GO:0034097 (response to cytokine)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0071806 (protein transmembrane transport)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:1903378 (positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)
GO:2000811 (negative regulation of anoikis)
GO:2001020 (regulation of response to DNA damage stimulus)
GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
Wikipedia MCL1

Target Cross References - Protein

canSAR Q07820
Human Protein Atlas ENSG00000143384
IntAct Q07820
Guide to Pharmacology 2847
Open Targets ENSG00000143384
PharmGKB PA30688
Reactome R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt B2R6B2 D3DV03 D3DV04 Q07820 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1

Target Cross References - Domain

InterPro IPR002475 (Bcl2-like.)
IPR013281 (Apop_reg_Mc1.)
IPR020717 (Bcl2_BH1_motif_CS.)
IPR020726 (Bcl2_BH2_motif_CS.)
IPR020728 (Bcl2_BH3_motif_CS.)
IPR026298 (Blc2_fam.)
Pfam PF00452 (Bcl-2)

Target Cross References - Structure

PDBe 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS More...
CREDO 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS More...
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