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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4342
Preferred Name Group X secretory phospholipase A2
Synonyms GX sPLA2 | Group 10 secretory phospholipase A2 | Group X secretory phospholipase A2 | PLA2G10 | Phosphatidylcholine 2-acylhydrolase 10 | sPLA2-X
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Group 10 secretory phospholipase A2 SINGLE PROTEIN O15496

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105659 VARESPLADIB METHYL Group X secretory phospholipase A2 inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000069764 ENSG00000276870
Ensembl ENSG00000069764 ENSG00000276870
GO Cellular Component GO:0005576 (extracellular region)
GO Molecular Function GO:0004620 (phospholipase activity)
GO:0004623 (phospholipase A2 activity)
GO:0005509 (calcium ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0007411 (axon guidance)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0010884 (positive regulation of lipid storage)
GO:0016042 (lipid catabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032308 (positive regulation of prostaglandin secretion)
GO:0036148 (phosphatidylglycerol acyl-chain remodeling)
GO:0036149 (phosphatidylinositol acyl-chain remodeling)
GO:0036150 (phosphatidylserine acyl-chain remodeling)
GO:0036151 (phosphatidylcholine acyl-chain remodeling)
GO:0036152 (phosphatidylethanolamine acyl-chain remodeling)
GO:0042632 (cholesterol homeostasis)
GO:0043030 (regulation of macrophage activation)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0051977 (lysophospholipid transport)
GO:0090238 (positive regulation of arachidonic acid secretion)
GO:0090370 (negative regulation of cholesterol efflux)
Wikipedia PLA2G10

Target Cross References - Protein

canSAR O15496
Human Protein Atlas ENSG00000069764 ENSG00000276870
IntAct O15496
Guide to Pharmacology 1422
Open Targets ENSG00000069764 ENSG00000276870
PharmGKB PA33360
Reactome R-HSA-1482788 (Acyl chain remodelling of PC.)
R-HSA-1482801 (Acyl chain remodelling of PS.)
R-HSA-1482839 (Acyl chain remodelling of PE.)
R-HSA-1482922 (Acyl chain remodelling of PI.)
R-HSA-1482925 (Acyl chain remodelling of PG.)
R-HSA-1483166 (Synthesis of PA.)
UniProt O15496 Q14DU3 Q6NT23

Target Cross References - Domain

InterPro IPR001211 (PLipase_A2.)
IPR016090 (PLipase_A2_dom.)
IPR033112 (PLipase_A2_Asp_AS.)
IPR033113 (PLipase_A2_His_AS.)
Pfam PF00068 (Phospholip_A2_1)

Target Cross References - Structure

PDBe 1LE6 1LE7 4UY1 5G3M