ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4338
Target Type SINGLE PROTEIN
Preferred Name Purine nucleoside phosphorylase
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Purine nucleoside phosphorylase SINGLE PROTEIN P00491

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198805
Ensembl ENSG00000198805
GO Cellular Component GO:0005856 (cytoskeleton)
GO:0005829 (cytosol)
GO:0005622 (intracellular)
GO:0070062 (extracellular exosome)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0008144 (drug binding)
GO:0042301 (phosphate ion binding)
GO:0004731 (purine-nucleoside phosphorylase activity)
GO:0001882 (nucleoside binding)
GO:0002060 (purine nucleobase binding)
GO Biological Process GO:0006148 (inosine catabolic process)
GO:0006195 (purine nucleotide catabolic process)
GO:0034418 (urate biosynthetic process)
GO:0042493 (response to drug)
GO:0044281 (small molecule metabolic process)
GO:0006738 (nicotinamide riboside catabolic process)
GO:0042102 (positive regulation of T cell proliferation)
GO:0006139 (nucleobase-containing compound metabolic process)
GO:0006955 (immune response)
GO:0043101 (purine-containing compound salvage)
GO:0034356 (NAD biosynthesis via nicotinamide riboside salvage pathway)
GO:0055086 (nucleobase-containing small molecule metabolic process)
GO:0046638 (positive regulation of alpha-beta T cell differentiation)
GO:0070970 (interleukin-2 secretion)
GO:0006144 (purine nucleobase metabolic process)
Wikipedia Purine_nucleoside_phosphorylase

Target Cross References - Protein

canSAR P00491
CGD Purine nucleoside phosphorylase deficiency
Human Protein Atlas ENSG00000198805
IntAct P00491
PharmGKB PA31694
UniProt B2R8S5 P00491 Q5PZ03 D3DS00 Q15160

Target Cross References - Domain

InterPro IPR001369 (PNP/MTAP.)
IPR011268 (Purine_phosphorylase.)
IPR000845 (Nucleoside_phosphorylase_d.)
IPR011270 (Pur_Nuc_Pase_Ino/Guo-sp.)
IPR018099 (Purine_phosphorylase-2_CS.)
Pfam PF01048 (PNP_UDP_1)

Target Cross References - Structure

PDBe 1ULA 1V41 2OC9 4ECE 4GKA 1M73 1RT9 1V2H 2OC4 1RR6 1ULB 2A0Y 3BGS 3INY 4EB8 1PF7 3GB9 3GGS 3K8O 4EAR 1RSZ 1V3Q 2A0W 2A0X More...
CREDO 1ULA 1V41 2OC9 4ECE 4GKA 1M73 1RT9 1V2H 2OC4 1RR6 1ULB 2A0Y 3BGS 3INY 4EB8 1PF7 3GB9 3GGS 3K8O 4EAR 1RSZ 1V3Q 2A0W 2A0X More...
spacer
spacer