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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4331
Target Type SINGLE PROTEIN
Preferred Name Hemoglobin beta chain
Synonyms Beta-globin | HBB | Hemoglobin beta chain | Hemoglobin subunit beta | LVV-hemorphin-7 | Spinorphin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Hemoglobin subunit beta SINGLE PROTEIN P68871

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095168 Hemoglobin HbA PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000244734
Ensembl ENSG00000244734
GO Cellular Component GO:0005833 (hemoglobin complex)
GO:0031838 (haptoglobin-hemoglobin complex)
GO Molecular Function GO:0005344 (oxygen transporter activity)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0030492 (hemoglobin binding)
GO Biological Process GO:0007596 (blood coagulation)
GO:0008217 (regulation of blood pressure)
GO:0010942 (positive regulation of cell death)
GO:0030185 (nitric oxide transport)
GO:0042744 (hydrogen peroxide catabolic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0050880 (regulation of blood vessel size)
GO:0051291 (protein heterooligomerization)
Wikipedia HBB

Target Cross References - Protein

canSAR P68871
CGD Beta-thalassemia; Sickle cell disease; Thalassemia-beta, dominant inclusion body; Other Thalassemias/Hemoglobinopathies
Human Protein Atlas ENSG00000244734
IntAct P68871
PharmGKB PA29202
Reactome REACT_604 (Hemostasis.)
UniProt A4GX73 B2ZUE0 P02023 P68871 Q13852 Q14481 Q14510 Q45KT0 Q549N7 Q6FI08 Q6R7N2 Q8IZI1 Q9BX96 Q9UCD6 Q9UCP8 Q9UCP9

Target Cross References - Domain

InterPro IPR000971 (Globin_subset.)
IPR002337 (Haemoglobin_b.)
IPR009050 (Globin-like.)
IPR012292 (Globin.)
Pfam PF00042 (Globin)

Target Cross References - Structure

PDBe 1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CBL 1CBM 1CH4 1CLS More...
CREDO 1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CBL 1CBM 1CH4 1CLS More...
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