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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4331
Preferred Name Hemoglobin beta chain
Synonyms Beta-globin | HBB | Hemoglobin beta chain | Hemoglobin subunit beta | LVV-hemorphin-7 | Spinorphin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Hemoglobin subunit beta SINGLE PROTEIN P68871

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000244734
Ensembl ENSG00000244734
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005829 (cytosol)
GO:0005833 (hemoglobin complex)
GO:0031838 (haptoglobin-hemoglobin complex)
GO:0070062 (extracellular exosome)
GO:0071682 (endocytic vesicle lumen)
GO:0072562 (blood microparticle)
GO:1904724 (tertiary granule lumen)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0005344 (oxygen transporter activity)
GO:0005515 (protein binding)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0030492 (hemoglobin binding)
GO:0031720 (haptoglobin binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006898 (receptor-mediated endocytosis)
GO:0007596 (blood coagulation)
GO:0008217 (regulation of blood pressure)
GO:0010942 (positive regulation of cell death)
GO:0015671 (oxygen transport)
GO:0015701 (bicarbonate transport)
GO:0030185 (nitric oxide transport)
GO:0042542 (response to hydrogen peroxide)
GO:0042744 (hydrogen peroxide catabolic process)
GO:0043312 (neutrophil degranulation)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0050880 (regulation of blood vessel size)
GO:0051291 (protein heterooligomerization)
GO:0070293 (renal absorption)
GO:0070527 (platelet aggregation)
GO:0098869 (cellular oxidant detoxification)
Wikipedia HBB

Target Cross References - Protein

canSAR P68871
CGD Beta-thalassemia; Sickle cell disease; Thalassemia-beta, dominant inclusion body; Other Thalassemias/Hemoglobinopathies
Human Protein Atlas ENSG00000244734
IntAct P68871
Open Targets ENSG00000244734
PharmGKB PA29202
Reactome R-HSA-1237044 (Erythrocytes take up carbon dioxide and release oxygen.)
R-HSA-1247673 (Erythrocytes take up oxygen and release carbon dioxide.)
R-HSA-2168880 (Scavenging of heme from plasma.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt A4GX73 B2ZUE0 P02023 P68871 Q13852 Q14481 Q14510 Q45KT0 Q549N7 Q6FI08 Q6R7N2 Q8IZI1 Q9BX96 Q9UCD6 Q9UCP8 Q9UCP9

Target Cross References - Domain

InterPro IPR000971 (Globin.)
IPR002337 (Haemoglobin_b.)
IPR009050 (Globin-like_sf.)
Pfam PF00042 (Globin)

Target Cross References - Structure

PDBe 1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CBL 1CBM 1CH4 1CLS More...
CREDO 1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CBL 1CBM 1CH4 1CLS More...