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Target Report Card

Target Name and Classification

Target ID CHEMBL4326
Target Type SINGLE PROTEIN
Preferred Name Fatty acid transport protein 2
Synonyms ACSVL1 | FACVL1 | FATP-2 | FATP2 | Fatty acid transport protein 2 | Fatty-acid-coenzyme A ligase, very long-chain 1 | Long-chain-fatty-acid--CoA ligase | SLC27A2 | Solute carrier family 27 member 2 | THCA-CoA ligase | VLACS | VLACS | VLCS | Very long-chain acyl-CoA synthetase | Very long-chain-fatty-acid-CoA ligase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc27 family of fatty acid transporters

Target Components

Component Description Relationship Accession
Very long-chain acyl-CoA synthetase SINGLE PROTEIN O14975

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140284
Ensembl ENSG00000140284
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005777 (peroxisome)
GO:0005778 (peroxisomal membrane)
GO:0005779 (integral component of peroxisomal membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030176 (integral component of endoplasmic reticulum membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004467 (long-chain fatty acid-CoA ligase activity)
GO:0005102 (receptor binding)
GO:0005524 (ATP binding)
GO:0015245 (fatty acid transporter activity)
GO:0016874 (ligase activity)
GO:0019899 (enzyme binding)
GO:0031957 (very long-chain fatty acid-CoA ligase activity)
GO:0050197 (phytanate-CoA ligase activity)
GO:0070251 (pristanate-CoA ligase activity)
GO:0102391 (decanoate--CoA ligase activity)
GO Biological Process GO:0000038 (very long-chain fatty acid metabolic process)
GO:0001561 (fatty acid alpha-oxidation)
GO:0001676 (long-chain fatty acid metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006635 (fatty acid beta-oxidation)
GO:0006699 (bile acid biosynthetic process)
GO:0008152 (metabolic process)
GO:0015908 (fatty acid transport)
GO:0042760 (very long-chain fatty acid catabolic process)
GO:0044539 (long-chain fatty acid import)
GO:0097089 (methyl-branched fatty acid metabolic process)
Wikipedia SLC27A2

Target Cross References - Protein

Human Protein Atlas ENSG00000140284
IntAct O14975
Open Targets ENSG00000140284
PharmGKB PA27971
Reactome R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-193775 (Synthesis of bile acids and bile salts via 24-hydroxycholesterol.)
R-HSA-389599 (Alpha-oxidation of phytanate.)
UniProt A8K2J7 O14975 Q53FY6 Q6PF09

Target Cross References - Domain

InterPro IPR000873 (AMP-dep_Synth/Lig.)
IPR020845 (AMP-binding_CS.)
IPR025110 (AMP-bd_C.)
IPR030305 (FATP2.)
Pfam PF00501 (AMP-binding)
PF13193 (AMP-binding_C)
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