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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4323
Target Type SINGLE PROTEIN
Preferred Name Phospholipase A2 group V
Synonyms Calcium-dependent phospholipase A2 | Group V phospholipase A2 | PLA2-10 | PLA2G5 | Phosphatidylcholine 2-acylhydrolase 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Calcium-dependent phospholipase A2 SINGLE PROTEIN P39877

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105659 VARESPLADIB METHYL Phospholipase A2 group V inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000127472
Ensembl ENSG00000127472
GO Cellular Component GO:0005576 (extracellular region)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004623 (phospholipase A2 activity)
GO:0005509 (calcium ion binding)
GO:0008201 (heparin binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0047498 (calcium-dependent phospholipase A2 activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006644 (phospholipid metabolic process)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0006663 (platelet activating factor biosynthetic process)
GO:0010518 (positive regulation of phospholipase activity)
GO:0016042 (lipid catabolic process)
GO:0019370 (leukotriene biosynthetic process)
GO:0034097 (response to cytokine)
GO:0036148 (phosphatidylglycerol acyl-chain remodeling)
GO:0036149 (phosphatidylinositol acyl-chain remodeling)
GO:0036150 (phosphatidylserine acyl-chain remodeling)
GO:0036151 (phosphatidylcholine acyl-chain remodeling)
GO:0036152 (phosphatidylethanolamine acyl-chain remodeling)
GO:0050482 (arachidonic acid secretion)
GO:0051591 (response to cAMP)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
Wikipedia PLA2G5

Target Cross References - Protein

canSAR P39877
CGD Fleck retina, familial benign
Human Protein Atlas ENSG00000127472
Guide to Pharmacology 1430
Open Targets ENSG00000127472
PharmGKB PA33366
Reactome R-HSA-1482788 (Acyl chain remodelling of PC.)
R-HSA-1482801 (Acyl chain remodelling of PS.)
R-HSA-1482839 (Acyl chain remodelling of PE.)
R-HSA-1482922 (Acyl chain remodelling of PI.)
R-HSA-1482925 (Acyl chain remodelling of PG.)
R-HSA-1483166 (Synthesis of PA.)
UniProt P39877 Q8N435

Target Cross References - Domain

InterPro IPR001211 (PLipase_A2.)
IPR016090 (PLipase_A2_dom.)
IPR033112 (PLipase_A2_Asp_AS.)
IPR033113 (PLipase_A2_His_AS.)
Pfam PF00068 (Phospholip_A2_1)
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