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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4311
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PAK6
Synonyms PAK-5 | PAK-6 | PAK5 | PAK6 | Serine/threonine-protein kinase PAK 6 | p21-activated kinase 6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase pakb subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 6 SINGLE PROTEIN Q9NQU5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137843
Ensembl ENSG00000137843
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005913 (cell-cell adherens junction)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0098641 (cadherin binding involved in cell-cell adhesion)
GO Biological Process GO:0000278 (mitotic cell cycle)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007010 (cytoskeleton organization)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0098609 (cell-cell adhesion)
Wikipedia PAK6

Target Cross References - Protein

canSAR Q9NQU5
Human Protein Atlas ENSG00000137843
IntAct Q9NQU5
Guide to Pharmacology 2137
Open Targets ENSG00000137843
PharmGKB PA32921
Pharos Q9NQU5 (Tchem)
Reactome R-HSA-428540 (Activation of Rac.)
UniProt A8K2G2 B3KYB0 G5E9R2 Q9NQU5

Target Cross References - Domain

InterPro IPR000095 (CRIB_dom.)
IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR033923 (PAK_BD.)
Pfam PF00069 (Pkinase)
PF00786 (PBD)

Target Cross References - Structure

PDBe 2C30 2ODB 4KS7 4KS8
CREDO 2C30 2ODB 4KS7 4KS8
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