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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4311
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PAK6
Synonyms PAK-5 | PAK-6 | PAK5 | PAK6 | Serine/threonine-protein kinase PAK 6 | p21-activated kinase 6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase pakb subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 6 SINGLE PROTEIN Q9NQU5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137843
Ensembl ENSG00000137843
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0005524 (ATP binding)
GO:0048365 (Rac GTPase binding)
GO:0004674 (protein serine/threonine kinase activity)
GO Biological Process GO:0007346 (regulation of mitotic cell cycle)
GO:0007266 (Rho protein signal transduction)
GO:0043408 (regulation of MAPK cascade)
GO:0030036 (actin cytoskeleton organization)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0006915 (apoptotic process)
GO:0032147 (activation of protein kinase activity)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0016477 (cell migration)
GO:0042981 (regulation of apoptotic process)
Wikipedia PAK6

Target Cross References - Protein

canSAR Q9NQU5
Human Protein Atlas ENSG00000137843
IntAct Q9NQU5
Guide to Pharmacology 2137 (p21 protein (Cdc42/Rac)-activated kinase 6)
PharmGKB PA32921
UniProt Q9NQU5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR000095 (CRIB_dom.)
IPR011009 (Kinase-like_dom.)
Pfam PF00786 (PBD)
PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4KS8 2C30 4KS7 2ODB
CREDO 4KS8 2C30 4KS7 2ODB
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