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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4306
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated potassium channel subunit Kv1.5
Synonyms HPCN1 | KCNA5 | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel HK2 | Voltage-gated potassium channel subunit Kv1.5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > voltage-gated potassium channel

Target Components

Component Description Relationship Accession
Potassium voltage-gated channel subfamily A member 5 SINGLE PROTEIN P22460

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2362996 Voltage-gated potassium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130037
Ensembl ENSG00000130037
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005249 (voltage-gated potassium channel activity)
GO:0005251 (delayed rectifier potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0005515 (protein binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006810 (transport)
GO:0006811 (ion transport)
Wikipedia KCNA5

Target Cross References - Protein

canSAR P22460
CGD Atrial fibrillation, familial, 7
Human Protein Atlas ENSG00000130037
IntAct P22460
Guide to Pharmacology 542
Open Targets ENSG00000130037
PharmGKB PA208
Pharos P22460 (Tclin)
Reactome R-HSA-1296072 (Voltage gated Potassium channels.)
UniProt P22460 Q4KKT8 Q4VAJ1 Q4VAJ2 Q9UDA4

Target Cross References - Domain

InterPro IPR000210 (BTB/POZ_dom.)
IPR003131 (T1-type_BTB.)
IPR003968 (K_chnl_volt-dep_Kv.)
IPR003972 (K_chnl_volt-dep_Kv1.)
IPR004052 (K_chnl_volt-dep_Kv1.5.)
IPR005821 (Ion_trans_dom.)
IPR011333 (SKP1/BTB/POZ.)
IPR027359 (Channel_four-helix_dom.)
IPR028325 (VG_K_chnl.)
Pfam PF00520 (Ion_trans)
PF02214 (BTB_2)
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