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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4296
Target Type SINGLE PROTEIN
Preferred Name Sodium channel protein type IX alpha subunit
Synonyms NENA | Neuroendocrine sodium channel | PN1 | Peripheral sodium channel 1 | SCN9A | Sodium channel protein type 9 subunit alpha | Sodium channel protein type IX subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 9 subunit alpha SINGLE PROTEIN Q15858

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2331043 Sodium channel alpha subunit PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3544913 RAXATRIGINE Sodium channel protein type IX alpha subunit blocker 2 Other PubMed
CHEMBL3545171 PF-05089771 Sodium channel protein type IX alpha subunit blocker 2 Other PubMed
CHEMBL3545012 DSP-2230 Sodium channel protein type IX alpha subunit blocker 1 Other
CHEMBL3545091 XEN403 Sodium channel protein type IX alpha subunit blocker 1 PubMed
CHEMBL3545208 AZD3161 Sodium channel protein type IX alpha subunit blocker 1 PubMed
CHEMBL3707353 RG7893 Sodium channel protein type IX alpha subunit blocker 0 Other Other
CHEMBL3707380 RG6029 Sodium channel protein type IX alpha subunit blocker 0 Other Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169432
Ensembl ENSG00000169432
GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042995 (cell projection)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005272 (sodium channel activity)
GO:0031402 (sodium ion binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0006954 (inflammatory response)
GO:0009636 (response to toxic substance)
GO:0009791 (post-embryonic development)
GO:0019228 (neuronal action potential)
GO:0019233 (sensory perception of pain)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0048266 (behavioral response to pain)
GO:0055085 (transmembrane transport)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0086010 (membrane depolarization during action potential)
Wikipedia Nav1.7

Target Cross References - Protein

CGD Paroxysmal extreme pain disorder
Human Protein Atlas ENSG00000169432
IntAct Q15858
Guide to Pharmacology 584
Open Targets ENSG00000169432
PharmGKB PA35010
Pharos Q15858 (Tclin)
Reactome R-HSA-445095 (Interaction between L1 and Ankyrins.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
UniProt A1BUH5 Q15858 Q6B4R9 Q6B4S0 Q6B4S1 Q70HX1 Q70HX2 Q8WTU1 Q8WWN4

Target Cross References - Domain

InterPro IPR000048 (IQ_motif_EF-hand-BS.)
IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans_dom.)
IPR010526 (Na_trans_assoc.)
IPR024583 (Na_trans_cytopl.)
IPR027359 (Channel_four-helix_dom.)
IPR028803 (SCN9A.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)
PF11933 (Na_trans_cytopl)

Target Cross References - Structure

PDBe 5EK0
CREDO 5EK0
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