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Target Report Card

Target Name and Classification

Target ID CHEMBL4284
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform
Synonyms PP2A subunit B isoform B55-alpha | PP2A subunit B isoform PR55-alpha | PP2A subunit B isoform R2-alpha | PP2A subunit B isoform alpha | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > protein phosphatase regulatory subunit

Target Components

Component Description Relationship Accession
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform SINGLE PROTEIN P63151

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000221914
Ensembl ENSG00000221914
GO Cellular Component GO:0000159 (protein phosphatase type 2A complex)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004722 (protein serine/threonine phosphatase activity)
GO:0005515 (protein binding)
GO:0008601 (protein phosphatase type 2A regulator activity)
GO:0032403 (protein complex binding)
GO:0048156 (tau protein binding)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000184 (nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)
GO:0006470 (protein dephosphorylation)
GO:0007084 (mitotic nuclear envelope reassembly)
GO:0034047 (regulation of protein phosphatase type 2A activity)
GO:0043278 (response to morphine)
Wikipedia PPP2R2A

Target Cross References - Protein

canSAR P63151
Human Protein Atlas ENSG00000221914
IntAct P63151
Open Targets ENSG00000221914
PharmGKB PA33668
Reactome R-HSA-2995383 (Initiation of Nuclear Envelope Reformation.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-69273 (Cyclin A/B1 associated events during G2/M transition.)
R-HSA-975957 (Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).)
UniProt B2RBU8 B4E1T7 P50409 P63151 Q00007

Target Cross References - Domain

InterPro IPR000009 (PP2A_PR55.)
IPR001680 (WD40_repeat.)
IPR015943 (WD40/YVTN_repeat-like_dom.)
IPR017986 (WD40_repeat_dom.)
IPR018067 (PP2A_PR55_CS.)

Target Cross References - Structure

PDBe 3DW8
CREDO 3DW8
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