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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4266
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated P/Q-type calcium channel alpha-1A subunit
Synonyms BI | Brain calcium channel I | CACH4 | CACN3 | CACNA1A | CACNL1A4 | Calcium channel, L type, alpha-1 polypeptide isoform 4 | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Voltage-gated calcium channel subunit alpha Cav2.1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent P/Q-type calcium channel subunit alpha-1A SINGLE PROTEIN O00555

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363032 Voltage-gated calcium channel PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141837
Ensembl ENSG00000141837
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0019905 (syntaxin binding)
GO Biological Process GO:0006112 (energy reserve metabolic process)
GO:0007204 (elevation of cytosolic calcium ion concentration)
GO:0008219 (cell death)
GO:0050796 (regulation of insulin secretion)
GO:0051899 (membrane depolarization)
Wikipedia Cav2.1

Target Cross References - Protein

canSAR O00555
CGD Episodic ataxia, type 2; Migraine, familial hemiplegic 1
Human Protein Atlas ENSG00000141837
IntAct O00555
Guide to Pharmacology 532 (Cav2.1)
PharmGKB PA26007
Reactome REACT_13685 (Synaptic Transmission.)
REACT_1505 (Integration of energy metabolism.)
REACT_15380 (Diabetes pathways.)
UniProt O00555 P78510 P78511 Q16290 Q92690 Q99790 Q99791 Q99792 Q99793 Q9UDC4

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005448 (VDCC_P/Q_a1su.)
IPR005821 (Ion_trans.)
IPR014873 (VDCC_a1su_IQ.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)

Target Cross References - Structure

PDBe 3BXK
CREDO 3BXK
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