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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4266
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated P/Q-type calcium channel alpha-1A subunit
Synonyms BI | Brain calcium channel I | CACH4 | CACN3 | CACNA1A | CACNL1A4 | Calcium channel, L type, alpha-1 polypeptide isoform 4 | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Voltage-gated calcium channel subunit alpha Cav2.1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent P/Q-type calcium channel subunit alpha-1A SINGLE PROTEIN O00555

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363032 Voltage-gated calcium channel PROTEIN COMPLEX GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL29919 ELPETRIGINE Voltage-gated P/Q-type calcium channel alpha-1A subunit blocker 0 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141837
Ensembl ENSG00000141837
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0098793 (presynapse)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0008331 (high voltage-gated calcium channel activity)
GO:0019905 (syntaxin binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000096 (sulfur amino acid metabolic process)
GO:0006006 (glucose metabolic process)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007270 (neuron-neuron synaptic transmission)
GO:0007274 (neuromuscular synaptic transmission)
GO:0007416 (synapse assembly)
GO:0007628 (adult walking behavior)
GO:0008219 (cell death)
GO:0014051 (gamma-aminobutyric acid secretion)
GO:0014056 (regulation of acetylcholine secretion, neurotransmission)
GO:0016049 (cell growth)
GO:0017156 (calcium ion regulated exocytosis)
GO:0017158 (regulation of calcium ion-dependent exocytosis)
GO:0019226 (transmission of nerve impulse)
GO:0021522 (spinal cord motor neuron differentiation)
GO:0021590 (cerebellum maturation)
GO:0021679 (cerebellar molecular layer development)
GO:0021680 (cerebellar Purkinje cell layer development)
GO:0021702 (cerebellar Purkinje cell differentiation)
GO:0021750 (vestibular nucleus development)
GO:0021953 (central nervous system neuron differentiation)
GO:0030644 (cellular chloride ion homeostasis)
GO:0032353 (negative regulation of hormone biosynthetic process)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0042133 (neurotransmitter metabolic process)
GO:0042391 (regulation of membrane potential)
GO:0042445 (hormone metabolic process)
GO:0043113 (receptor clustering)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0048265 (response to pain)
GO:0048266 (behavioral response to pain)
GO:0048791 (calcium ion-regulated exocytosis of neurotransmitter)
GO:0048813 (dendrite morphogenesis)
GO:0050770 (regulation of axonogenesis)
GO:0050796 (regulation of insulin secretion)
GO:0050877 (neurological system process)
GO:0050883 (musculoskeletal movement, spinal reflex action)
GO:0050885 (neuromuscular process controlling balance)
GO:0050905 (neuromuscular process)
GO:0051899 (membrane depolarization)
GO:0055085 (transmembrane transport)
GO:0060024 (rhythmic synaptic transmission)
GO:0070588 (calcium ion transmembrane transport)
GO:0086010 (membrane depolarization during action potential)
Wikipedia Cav2.1

Target Cross References - Protein

canSAR O00555
CGD Episodic ataxia, type 2; Migraine, familial hemiplegic 1
Human Protein Atlas ENSG00000141837
IntAct O00555
Open Targets ENSG00000141837
PharmGKB PA26007
Pharos O00555 (Tchem)
Reactome R-HSA-112308 (Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.)
R-HSA-422356 (Regulation of insulin secretion.)
UniProt J3KP41 O00555 P78510 P78511 Q16290 Q92690 Q99790 Q99791 Q99792 Q99793 Q9NS88 Q9UDC4

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005448 (CACNA1A.)
IPR005821 (Ion_trans_dom.)
IPR014873 (VDCC_a1su_IQ.)
IPR027359 (Channel_four-helix_dom.)
IPR031649 (GPHH_dom.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)
PF16905 (GPHH)

Target Cross References - Structure

PDBe 3BXK
CREDO 3BXK
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